PMID: 9431574Feb 7, 1998Paper

Modulation of ovarian follicle maturation and effects on apoptotic cell death in Holtzman rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero and lactationally

Reproductive Toxicology
I HeimlerReinhold J Hutz

Abstract

Recent reports have described the reproduction-modulating and endocrine-disrupting effects following exposure to toxic substances such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Herein, we set out (1) to determine whether TCDD exposure exerts detrimental effects on follicle maturation in the Holtzman rat ovary and (2) to determine whether the effects of TCDD are mediated in part via apoptotic cell death. In certain species, dioxin exposure is correlated with reduced fecundity, reduced ovulatory rate, an increased incidence of endometriosis, and various reproductive cancers. Although some of the effects of TCDD are mediated via the hypothalamic-pituitary axis, direct effects on the ovary have also been observed. In the present study, an oral dose of 1 microgram TCDD/kg maternal body weight was administered on Day 15 of gestation. Female pups were sacrificed on Postnatal Day 21/22, and the ovaries were excised, fixed for histologic analysis, and analyzed in a double-blind paradigm. The analysis included a count and measurement and classification of preantral and antral follicles throughout the entire ovary. The contralateral ovary from each animal was analyzed for DNA fragmentation indicative of apoptotic cell death. The resu...Continue Reading

References

Sep 15, 1979·Toxicology and Applied Pharmacology·F J MurrayB A Schwetz

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Citations

Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Dec 26, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Charbel MassaadSamir Hamamah
Aug 8, 2001·Reproductive Toxicology·F M MoránB L Lasley
May 23, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·B J StantonB L Lasley
Jan 29, 2002·International Immunopharmacology·Nancy I Kerkvliet
Apr 22, 2006·The Journal of Reproduction and Development·H M HoReinhold J Hutz
Sep 20, 2006·The Journal of Reproduction and Development·Mariko ShirotaKinji Shirota
Apr 7, 2010·Environmental Health Perspectives·Warren G FosterDaniel G Cyr
Nov 23, 2012·Environmental Health Perspectives·Marina VafeiadiManolis Kogevinas
Dec 31, 2003·Environmental Health Perspectives·Brenda EskenaziPaolo Brambilla
Sep 4, 2004·Environmental Health Perspectives·Marcella WarnerBrenda Eskenazi
Jul 9, 2005·Environmental Health Perspectives·Brenda EskenaziPaolo Mocarelli
Apr 14, 2007·Environmental Health Perspectives·Marcella WarnerPaolo Mocarelli
Apr 15, 2007·Pakistan Journal of Biological Sciences : PJBS·A S M FouzyA M Hammam
Oct 6, 2009·General and Comparative Endocrinology·Riadh BadraouiTarek Rebai
Sep 19, 2006·Chemico-biological Interactions·Richard S Pollenz, Christine Buggy
Sep 13, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Veerle BruggemanEddy Decuypere
Jun 13, 2015·Biology of Reproduction·Shreya PatelJodi A Flaws
Jun 29, 2011·Ciência & saúde coletiva·Warren G FosterDaniel G Cyr
Jul 15, 2017·Archives of Physiology and Biochemistry·Latifa HamdaouiTarek Rebai
Jul 20, 2018·International Journal of Environmental Health Research·Melanie C BuserHana R Pohl
Dec 16, 2006·American Journal of Primatology·Monika G Baldridge, Reinhold J Hutz
Sep 6, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·S A MyllymäkiJ Paranko
Apr 19, 2020·Reviews on Environmental Health·Serena BianchiGuido Macchiarelli

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