Modulation of pain by [1DMe]NPYF, a stable analogue of neuropeptide FF, in neuropathic rats

Brain Research
Hong WeiAntti Pertovaara

Abstract

The pain modulatory effects of (D-Tyr)L(Me-Phe)QPQRF-amide ([1DMe]NPYF), a stable analogue of neuropeptide FF were studied in rats with a chronic neuropathy induced by unilateral ligation of two spinal nerves. According to behavioral assessments, intrathecal (i.t.) administration of [1DMe]NPYF induced mechanical antiallodynic and thermal antinociceptive effects in a parallel and dose-dependent fashion, whereas following administration in the periaqueductal gray (PAG) it produced only mechanical antiallodynia. I.t. or PAG administration of FLFQPQRF, a non-amidated form of NPFF, or intraplantar injection of [1DMe]NPYF into the neuropathic paw had no effects. Electrophysiological results indicated that administration of [1DMe]NPYF suppressed responses of nociceptive spinal dorsal horn neurons in a submodality selective way and without an effect on their spontaneous activity; PAG administration predominantly suppressed brush-evoked responses and i.t. administration heat-evoked responses. The descending inhibitory effect by conditioning electrical stimulation of the PAG was enhanced by i.t. administration of [1DMe]NPYF. The reversibility of [1DMe]NPYF-induced effects by naloxone (1 mg/kg subcutaneously) depended on the submodality o...Continue Reading

Citations

Apr 1, 2010·The Journal of Pharmacology and Experimental Therapeutics·Jelveh LamehLuis R Gardell
Aug 31, 2010·BioFactors·Lionel MoulédousJean-Marie Zajac
Sep 16, 2019·The Journal of Pain : Official Journal of the American Pain Society·Zilong WangQuan Fang
Sep 22, 2018·Life Sciences·Fahimeh NourbakhshAli Roohbakhsh
May 30, 2002·Progress in Neurobiology·Mark J Millan

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