Modulation of pan-cadherin expression in alveolar epithelial cells of mini pigs with pulmonary fibrosis

Acta histochemica
M Kasper, M Müller

Abstract

The expression of pan-cadherin was investigated immunohistochemically in normal and irradiated mini pig lungs. Using a double labelling immunofluorescence technique, pan-cadherin expression was also compared with that of cytokeratin 18, which is selectively present in type II cells. In untreated animals pan-cadherin was detected in type I pneumocytes, in alveolar macrophages and in endothelial cells of larger blood vessels. Radiation caused increased pan-cadherin immunoreactivity of bronchial epithelial cells and interstitial cells. In addition, pan-cadherin expression was induced in type II pneumocytes. These changes in the distribution of epithelial cadherin molecules may implicate a role of cadherins for epithelial remodeling in response to radiation-induced lung injury.

References

Mar 1, 1991·Respiratory Medicine·S Montefort, S T Holgate
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Oct 1, 1993·American Journal of Respiratory Cell and Molecular Biology·B H KangL Y Chang
Dec 1, 1993·The American Review of Respiratory Disease·J M Pilewski, S M Albelda

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Citations

Mar 29, 2002·American Journal of Respiratory Cell and Molecular Biology·Richard L AutenS Nicholas Mason

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