Modulation of pathogen recognition by autophagy.

Frontiers in Immunology
Ji Eun Oh, Heung Kyu Lee

Abstract

Autophagy is an ancient biological process for maintaining cellular homeostasis by degradation of long-lived cytosolic proteins and organelles. Recent studies demonstrated that autophagy is availed by immune cells to regulate innate immunity. On the one hand, cells exert direct effector function by degrading intracellular pathogens; on the other hand, autophagy modulates pathogen recognition and downstream signaling for innate immune responses. Pathogen recognition via pattern recognition receptors induces autophagy. The function of phagocytic cells is enhanced by recruitment of autophagy-related proteins. Moreover, autophagy acts as a delivery system for viral replication complexes to migrate to the endosomal compartments where virus sensing occurs. In another case, key molecules of the autophagic pathway have been found to negatively regulate immune signaling, thus preventing aberrant activation of cytokine production and consequent immune responses. In this review, we focus on the recent advances in the role of autophagy in pathogen recognition and modulation of innate immune responses.

Citations

Nov 28, 2013·Seminars in Immunology·Leo A B JoostenCharles A Dinarello
Jul 28, 2012·Journal of Virology·Bjorn-Patrick MohlMark Harris
Apr 6, 2013·Immune Network·Ji Eun Oh, Heung Kyu Lee
Sep 20, 2019·International Forum of Allergy & Rhinology·Jing Li, Yong Li
Feb 7, 2013·The Journal of Biological Chemistry·Kathrin BuffenLeo A B Joosten
Jul 13, 2017·International Journal of Molecular Sciences·Hiroshi TazawaToshiyoshi Fujiwara
Mar 7, 2019·Immune Network·Jinju Lee, Hun Sik Kim
Jun 12, 2021·Frontiers in Immunology·Tamiris Lameira BittencourtRoberta Olmo Pinheiro

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Methods Mentioned

BETA
nucleotide exchange
ubiquitination

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