Modulation of PDGF mediated osteoblast chemotaxis by leukemia inhibitory factor (LIF)

Journal of Cellular Physiology
S Chandrasekhar, A K Harvey

Abstract

Cell migration is a key event in tissue repair and remodeling. PDGF, a growth factor for multiple target cells, has been shown to be a potent chemoattractant for a variety of mesenchymal cells. However, it is likely that PDGF-mediated cell migration will be influenced by other cytokines that can be produced during physiological and pathological conditions. Leukemia inhibitory factor (LIF), a cytokine that is produced by a variety of cells including osteoblasts, may promote bone formation, but the mechanism is not known. Since osteoblasts are responsible for laying down new matrix during skeletal remodeling, in this report we have examined whether PDGF or LIF influences the migration of osteoblasts. Among several cytokines and growth factors tested, only PDGF was able to elicit a major chemotactic (directed migration) and a minor chemokinetic (random-migration) response in osteoblasts. LIF alone was not active in either chemotaxis or chemokinesis but when included with PDGF it caused a reduction in chemokinesis. Further, pretreatment of osteoblasts with LIF caused an increase in PDGF-driven chemotaxis. Finally, osteoblasts exposed briefly to LIF synthesized a higher level of non-collagenous proteins upon further treatment with P...Continue Reading

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Citations

Sep 25, 2004·Journal of Cellular Physiology·Nalini S MakhijaniDean T Yamaguchi
Oct 28, 2008·PloS One·Maria Arantzazu Sanchez-FernandezBernard Hoflack
Apr 27, 2016·Journal of Theoretical Biology·Jennifer Paola Corredor-GómezCarlos Julio Cortés-Rodríguez
Jun 27, 2003·The Journal of Craniofacial Surgery·Wanda E OpreaJohn E Davies
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hua ZhangJames E Faber

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