PMID: 9535541Apr 16, 1998Paper

Modulation of peripheral inflammation by locally administered hemorphin-7

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
K SandersonZ Khalil

Abstract

Sensory nerves mediate peripheral inflammation via the release of sensory peptides at the site of tissue injury. Using a blister model of inflammation, we have previously documented that endogenous opioids modulate chronic but not acute inflammation. Hemorphins are nonclassical opioid peptides found in the region of the beta-chain of hemoglobin (Hb). The heptapeptide hemorphin-7 is identical with residues 35-41 of the beta-chain of the human Hb. The aim of this study was to examine the effect of hemorphin-7 on the inflammatory response in acute and chronic injury models. We have used a vacuum-induced blister model in the footpad of anaesthetized rats to induce an inflammatory response in naive skin by (a) electrical stimulation (ES) of the distal end of the cut sciatic nerve at 20 V, 5 Hz, 2 ms for 1 min or (b) superfusion of sensory peptides; substance P (SP) or calcitonin gene related peptide (CGRP) over the blister base. In addition, we examined the effect of hemorphin-7 on the inflammatory response to SP induced in a previously injured but healed skin site (recurrent injury model) and in denervated skin site due to chronic nerve lesion (chronic injury model). The results showed that prior and concomitant perfusion of hemorp...Continue Reading

Citations

Feb 16, 2010·General Thoracic and Cardiovascular Surgery·Nasser Safaii, Babak Kazemi
Aug 6, 2013·Peptides·Natalia M RibeiroCamila S Dale
Mar 10, 2001·Biochemical and Biophysical Research Communications·J SzikraA Borsodi
Mar 7, 2014·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Chang Zheng SongChang Cheng Song
Dec 8, 2009·Neurochemical Research·Nina BarkhudaryanFriedrich Lottspeich
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Jan 18, 2005·Peptides·Camila Squarzoni DaleEmer Suavinho Ferro
May 12, 2004·The American Journal of Cardiology·Michael MarmorRobert Maslansky
Apr 23, 2009·The International Journal of Social Psychiatry·Mahdi NajafiMahmood Sheikhfathollahi
Mar 3, 2004·Journal of Neuroscience Research·Anne PoljakGeorge A Smythe
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Tiphaine DejouvencelOlivier Meilhac
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Oct 16, 2019·Scientific Reports·Amanat AliRanjit Vijayan
Jan 27, 2019·Drug Development Research·Petar TodorovJana Tchekalarova
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Apr 4, 2021·Pharmaceuticals·Mohammed Akli Ayoub, Ranjit Vijayan
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Przemyslaw MielczarekJerzy Silberring

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