Modulation of Plant Salicylic Acid-Associated Immune Responses via Glycosylation of Dihydroxybenzoic Acids

Plant Physiology
Xu-Xu HuangBing-Kai Hou

Abstract

Salicylic acid (SA) plays a crucial role in plant innate immunity. The deployment of SA-associated immune responses is primarily affected by SA concentration, which is determined by a balance between SA biosynthesis and catabolism. However, the mechanisms regulating SA homeostasis are poorly understood. In this study, we characterized a unique UDP-glycosyltransferase, UGT76D1, which plays an important role in SA homeostasis and associated immune responses in Arabidopsis (Arabidopsis thaliana). Expression of UGT76D1 was induced by treatment with both the pathogen Pseudomonas syringae pv. tomato (Pst) DC3000 and SA. Overexpression of UGT76D1 resulted in high SA accumulation, significant up-regulation of pathogen-related genes, and a hypersensitive response (HR)-like lesion mimic phenotype. This HR-like phenotype was not observed following UGT76D1 overexpression in SA-deficient NahG transgenic or sid2 plants, suggesting that the phenotype is SA dependent. Biochemical assays showed that UGT76D1 glycosylated 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-dihydroxybenzoic acid (2,5-DHBA), the major catabolic forms of SA, to their Glc and Xyl conjugates in vitro and in vivo. Moreover, in a mutant background blocked in the formation of 2...Continue Reading

Citations

Aug 17, 2019·International Journal of Molecular Sciences·Dylan R ZeissIan A Dubery
Oct 28, 2019·BMC Plant Biology·Laura CamposPurificación Lisón
Dec 14, 2019·Plant Methods·Yahui LiuLanping Guo
Oct 24, 2018·International Journal of Molecular Sciences·Bernardus C J SchimmelMerijn R Kant
Sep 7, 2019·International Journal of Molecular Sciences·Igor PokotyloEric Ruelland
Apr 2, 2021·Plant Physiology·Fei ZhouEran Pichersky
Jun 1, 2021·Current Opinion in Plant Biology·Jürgen Zeier
Mar 24, 2021·Annual Review of Plant Biology·Yujun PengYuelin Zhang
Jul 22, 2021·The New Phytologist·Eduardo Mateo-BonmatíKarin Ljung
Apr 23, 2020·Journal of Agricultural and Food Chemistry·Zhiqiang GaoLiyong Cao
Oct 4, 2020·Journal of Natural Products·Dariya D FedorovaElena V Stepanova
Aug 27, 2021·Metabolites·James William AllwoodPierre Pétriacq
Mar 23, 2019·Current Opinion in Plant Biology·Yuelin Zhang, Xin Li

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