Modulation of pre-capillary arteriolar pressure with drag-reducing polymers: a novel method for enhancing microvascular perfusion.

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
John J PacellaFlordeliza S Villanueva

Abstract

We have shown that drag-reducing polymers (DRP) enhance capillary perfusion during severe coronary stenosis and increase red blood cell velocity in capillaries, through uncertain mechanisms. We hypothesize that DRP decreases pressure loss from the aorta to the arteriolar compartment. Intravital microscopy of the rat cremaster muscle and measurement of pressure in arterioles (diameters 20-132 μm) was performed in 24 rats. DRP (polyethylene oxide, 1 ppm) was infused i.v. and measurements were made at baseline and 20 minutes after completion of DRP infusion. In a 10-rat subset, additional measurements were made three minutes after the start, and one to five and 10 minutes after completion of DRP. Twenty minutes after the completion of DRP, mean arteriolar pressure was 22% higher than baseline (from 42 ± 3 to 49 ± 3 mmHg, p < 0.005, n = 24). DRP decreased the pressure loss from the aorta to the arterioles by 24% (from 35 ± 6 to 27 ± 5 mmHg, p = 0.001, n = 10). In addition, there was a strong trend toward an increase in pressure at 10 minutes after the completion of DRP (n = 10). Drag-reducing polymers diminish pressure loss between the aorta and the arterioles. This results in a higher pre-capillary pressure and probably explains t...Continue Reading

References

Apr 6, 2002·Journal of Biomechanics·Dieter Liepsch
Aug 18, 2006·European Heart Journal·John J PacellaFlordeliza S Villanueva
May 5, 1896·The Journal of Physiology·E H Starling
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Peter F Davies
Sep 2, 2009·Biorheology·John J PacellaFlordeliza S Villanueva
May 24, 2011·Critical Care Medicine·Jeffrey C Trost, Richard A Lange

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Citations

Apr 17, 2016·The Journal of Surgical Research·Zhenhua ZengZhongqing Chen
Jan 26, 2010·Journal of Pharmacological and Toxicological Methods·Ellen L Hughes, Felicity N E Gavins
Oct 15, 2010·Medical Engineering & Physics·Efstathios KaliviotisStavroula Balabani
Feb 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Denis E BraginEdwin M Nemoto

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