Modulation of presynaptic inhibition of la afferents during voluntary wrist flexion and extension in man

Experimental Brain Research
C AymardS Raoul

Abstract

Changes in presynaptic inhibition of Ia terminals directed to flexor carpi radialis (FCR) motoneurones (MNs) were investigated in normal human subjects at rest and during voluntary wrist flexion and extension. To that end, two independent methods were used: (1) the radial-induced D1 inhibition of the FCR H reflex, which assesses the excitability of PAD (primary afferent depolarisation) interneurones controlling presynaptic inhibition of Ia terminals mediating the afferent volley of the FCR H reflex; and (2) the heteronymous monosynaptic Ia facilitation induced in the FCR H reflex by intrinsic muscle Ia afferent stimulation, which assesses the ongoing presynaptic inhibition of Ia terminals. With respect to results at rest, it was found that at the onset of (and during tonic) voluntary wrist flexion, D1 inhibition was reduced and heteronymous monosynaptic Ia facilitation was increased. This suggests that, as in the lower limb, presynaptic inhibition is decreased on Ia terminals projecting to MNs involved in the voluntary contraction. In contrast with results observed in the lower limb, presynaptic inhibition of Ia terminals to FCR MNs was also found to be reduced at the onset of a voluntary contraction involving the antagonistic ...Continue Reading

Citations

Nov 20, 2004·Experimental Brain Research·Timothy J CarrollDavid F Collins
Jul 30, 2009·Experimental Brain Research·Stéphane Baudry, Roger M Enoka
Nov 11, 2011·Experimental Brain Research·C Minos NiuMark B Shapiro
Sep 12, 2002·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Masaki FumotoYoshiaki Nishihira
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Mar 30, 2016·Annual Review of Neuroscience·Jens Bo Nielsen
Apr 29, 2016·Journal of Neurophysiology·Alan J McComas
Feb 17, 2017·Experimental Brain Research·Laura KyguolieneMarius Brazaitis

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