PMID: 9436724Jan 22, 1998Paper

Modulation of primary orthostatic tremor by magnetic stimulation over the motor cortex

Journal of Neurology, Neurosurgery, and Psychiatry
C H TsaiP D Thompson

Abstract

To study the role of corticomotor neuronal pathways in primary orthostatic tremor. Transcranial magnetic stimuli at an intensity 10% above the resting motor threshold were delivered over the leg motor cortex in two patients with primary orthostatic tremor while standing still. Electromyographic responses in both tibialis anterior muscles were recorded after 20 stimuli given randomly at intervals of 120 to 180 seconds. Differences between predicted and actual times of occurrence of tremor bursts after the stimuli were used to calculate a resetting index, with a value of 0 representing no resetting and a value of 1 representing complete resetting. Transcranial magnetic stimulation evoked EMG responses in both tibialis anterior muscles, followed by transient suppression of tremor before reappearance of rhythmic EMG activity. Analysis of the timing of tremor bursts from EMG recordings before and after the magnetic stimuli disclosed that the phase of orthostatic tremor could be reset by brain stimulation (mean resetting indices 0.93 and 0.82). The results suggest that a central oscillator, involving the motor cortex, has a crucial role in either the generation or modulation of orthostatic tremor.

Citations

Apr 11, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·Y R WuA E Lang
Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J SpiegelU Dillmann
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Nov 19, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Roberto Cantello
Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·B BoroojerdiM Schwarz
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E ApartisM Vidailhet
Jun 27, 2009·Neurologic Clinics·Rodger J Elble
Dec 11, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Paul F SowmanTimothy S Miles
Apr 7, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Rob M A de BieAnthony E Lang
Aug 4, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Smaranda Leu-SemenescuEmmanuelle Apartis
Nov 3, 2004·Neuroscience Letters·Agnes P Funk, Charles M Epstein
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Oct 27, 2018·Movement Disorders Clinical Practice·Danish BhattiDiego Torres-Russotto
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