Modulation of quinidine-induced arrhythmias by temperature in perfused rabbit heart

The American Journal of Physiology
J F Spear, E N Moore

Abstract

We used low temperature to slow ion channel kinetics and studied the electrophysiological effects of quinidine at different pacing rates in isolated rabbit hearts. Fifteen epicardial electrograms together with an endocardial monophasic action potential were recorded. Epicardial activation and local recovery times were measured. Arrhythmias together with the characteristics of their mode of induction and rate were analyzed by epicardial activation sequence mapping. In the presence of quinidine, arrhythmias consistent with both triggered activity and reentry were observed. At baseline, triggered activity was not inducible, even though at 25 degrees C the recovery time was greater than that in the presence of quinidine at 36 degrees C. Also, with quinidine, the incidence of triggered activity decreased at 30 and 25 degrees C. Therefore prolongation of the recovery time per se does not cause triggered activity. Quinidine's use-dependent effects on conduction and reverse use-dependent effects on recovery time were amplified by low temperatures. These findings can be understood in terms of the known temperature sensitivities of the kinetics of the membrane ion channels responsible for activation and recovery. The results demonstrate ...Continue Reading

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Citations

Jun 26, 2003·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin
Aug 2, 2003·American Journal of Physiology. Renal Physiology·Yuan WeiWen-Hui Wang
Feb 25, 2005·American Journal of Physiology. Renal Physiology·Daniel A GrayLawrence G Palmer
Oct 6, 2005·American Journal of Physiology. Renal Physiology·Dimin LiWen-Hui Wang
Apr 28, 2006·American Journal of Physiology. Renal Physiology·Tetsuji MorimotoThomas R Kleyman
May 4, 2007·American Journal of Physiology. Renal Physiology·Ruimin GuBaofeng Yang
Oct 5, 2007·American Journal of Physiology. Cell Physiology·Christine AlewinePaul A Welling
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J F Spear, E N Moore
Jul 20, 2006·American Journal of Physiology. Renal Physiology·Lisa M SatlinThomas R Kleyman
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Dao-Hong LinWen-Hui Wang
Mar 28, 2008·American Journal of Physiology. Renal Physiology·Sahran LachhebMarc Paulais
Aug 8, 2008·American Journal of Physiology. Renal Physiology·Huda Ismail AbdullahNicholas R Ferreri
Oct 26, 2006·American Journal of Physiology. Renal Physiology·Lawrence G Palmer, Gustavo Frindt
Jan 11, 2008·American Journal of Physiology. Cell Physiology·Yan ZhangWen-Hui Wang
Dec 14, 2006·American Journal of Physiology. Renal Physiology·Yuan WeiWenhui Wang
Apr 17, 2009·American Journal of Physiology. Renal Physiology·Shoujin HaoNicholas R Ferreri
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Aug 2, 2003·American Journal of Physiology. Renal Physiology·Tong WangWen-Hui Wang
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Feb 13, 2009·American Journal of Physiology. Renal Physiology·Yan JinWen-Hui Wang
Sep 24, 2004·Physiological Reviews·Carsten A WagnerJohn P Geibel
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Aug 10, 2007·American Journal of Physiology. Renal Physiology·Yan JinWen-Hui Wang

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