Modulation of quorum sensing-controlled virulence factors by Nymphaea tetragona (water lily) extract

Journal of Ethnopharmacology
Md Akil HossainSeung-Chun Park

Abstract

Nymphaea tetragona is a widely distributed ornamental species with ethnomedicinal uses in the treatment of diarrhea, dysentery, eruptive fevers, and infections. The anti-infectious activities of this herb have already been assessed to clarify its traditional use as a medicine. In this study, we aimed to verify the inhibitory effects of N. tetragona 50% methanol extract (NTME) on quorum sensing (QS)-controlled virulence factors of bacteria since QS and its virulence factors are novel targets for antimicrobial therapy. The antibacterial activity of this extract was evaluated against Chromobacterium violaceum and Pseudomonas aeruginosa. The inhibition of the violacein pigment of C. violaceum by NTME was determined qualitative and quantitative using standard methods. The effects of NTME on swarming motility, biofilm viability, pyocyanin production, and LasA protease activity were evaluated using P. aeruginosa. Finally, the in vitro and in vivo cytotoxicity of NTME were verified by MTT assay and oral administration to rats, respectively. The extract had concentration-dependent antibacterial activity against gram-negative bacteria. NTME at 1/2× minimum inhibitory concentration (MIC), 1× MIC and 2× MIC significantly lowered the levels...Continue Reading

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Citations

Jul 22, 2016·The Journal of Bone and Joint Surgery. American Volume·Arvind NanaAntonia F Chen
Jul 1, 2020·BioMed Research International·Min YangJie Yu
May 5, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Md Akil HossainSeung-Chun Park
Sep 26, 2017·Asian Pacific Journal of Tropical Medicine·Abdelhakim BouyahyaYoussef Bakri

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