Modulation of Radiation Response by the Tetrahydrobiopterin Pathway

Antioxidants
Rupak PathakNukhet Aykin-Burns

Abstract

Ionizing radiation (IR) is an integral component of our lives due to highly prevalent sources such as medical, environmental, and/or accidental. Thus, understanding of the mechanisms by which radiation toxicity develops is crucial to address acute and chronic health problems that occur following IR exposure. Immediate formation of IR-induced free radicals as well as their persistent effects on metabolism through subsequent alterations in redox mediated inter- and intracellular processes are globally accepted as significant contributors to early and late effects of IR exposure. This includes but is not limited to cytotoxicity, genomic instability, fibrosis and inflammation. Damage to the critical biomolecules leading to detrimental long-term alterations in metabolic redox homeostasis following IR exposure has been the focus of various independent investigations over last several decades. The growth of the "omics" technologies during the past decade has enabled integration of "data from traditional radiobiology research", with data from metabolomics studies. This review will focus on the role of tetrahydrobiopterin (BH4), an understudied redox-sensitive metabolite, plays in the pathogenesis of post-irradiation normal tissue injur...Continue Reading

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Citations

Jul 12, 2016·Antioxidants·Susan HallShailendra Anoopkumar-Dukie
Nov 1, 2018·Cellular and Molecular Life Sciences : CMLS·Bjorn BaseletAn Aerts
Feb 2, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Magy SallamAn Aerts
Mar 24, 2021·Neurochemical Research·Noura Magdy ThabetEnas Mahmoud Moustafa
Jul 25, 2021·British Journal of Pharmacology·Christophe KleinMaria Chiara Maiuri

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