Modulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic field

International Journal of Radiation Biology
Marko DinčićJasna Todorović

Abstract

It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for ...Continue Reading

References

Jan 1, 1993·Radiation and Environmental Biophysics·S StegemannL E Feinendegen
Sep 5, 2002·Bioelectromagnetics·Stefan EngströmJulia M Markov
Feb 11, 2003·Progress in Neurobiology·J A RibeiroA de Mendonça
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Sep 30, 2003·Cell Biochemistry and Biophysics·Arthur D Rosen
Jul 9, 2004·Journal of the Neurological Sciences·Abigail CootsArthur D Rosen
Jan 19, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Laura TeodoriAugusto Accorsi
Mar 27, 2007·Annals of the New York Academy of Sciences·M De NicolaL Ghibelli
Mar 27, 2007·Annals of the New York Academy of Sciences·S NuccitelliL Ghibelli
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Hideyuki Okano
Dec 29, 2009·General Physiology and Biophysics·Salem AmaraHafedh Abdelmelek
Jan 29, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Feng GaoHong Zhang
May 26, 2012·Ecotoxicology and Environmental Safety·Drago M DjordjevichAlexander M Trbovich
Nov 2, 2013·Current Neuropharmacology·Mirjana B ColovićVesna M Vasić
Jun 6, 2014·International Journal of Radiation Biology·Aïda LahbibHafedh Abdelmelek
Sep 17, 2014·Trends in Pharmacological Sciences·Beáta Sperlágh, Peter Illes
Dec 3, 2014·Biochemical Pharmacology·Sang-Yong LeeChrista E Müller
Jun 13, 2015·Environmental Science and Pollution Research International·Soumaya GhodbaneHafedh Abdelmelek
Jul 15, 2015·Neuropsychiatric Disease and Treatment·Philip G Janicak, Mehmet E Dokucu
Aug 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Takayuki OhnishiMinako Hoshi
Feb 7, 2016·International Journal of Radiation Biology·Silvio R De LukaAlexander M Trbovich
Apr 16, 2016·Environmental Science and Pollution Research International·Katarzyna Pawłowska-GóralStanisław Gawron
Jul 11, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Marie-Claire Smith, Cathy M Stinear
Dec 23, 2016·Environmental Science and Pollution Research International·Eduardo B DornellesIvana B M da Cruz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.