PMID: 9447874Feb 3, 1998Paper

Modulation of recombination human gamma-aminobutyric acidA receptors by isoflurane: influence of the delta subunit

Anesthesiology
G Lees, M D Edwards

Abstract

The gamma-aminobutyric acid (GABA)A receptor/chloride channel has a broad-spectrum anesthetic sensitivity and is a key regulator of arousal. Each receptor/channel complex is an assembly of five protein subunits. Six subunit classes have been identified, each containing one to six members; many combinations are expressed throughout the brain. Benzodiazepines and intravenous anesthetic agents are clearly subunit dependent, but the literature to date suggests that volatile anesthetics are not. The physiological role of the delta subunit remains enigmatic, and it has not been examined as a determinant of anesthetic sensitivity. Combinations of GABA(A) receptor subunit cDNAs were injected into Xenopus laevis oocytes: alpha1beta1, alpha1beta1gamma2L, alpha1beta1delta, and alpha1beta1gamma2Ldelta. Expression of functional ion channels with distinct signalling and pharmacologic properties was demonstrated within 1-4 days by established electrophysiological methods. Co-expression of the delta subunit produced changes in receptor affinity; current density; and the modulatory efficacy of diazepam, zinc, and lanthanum; it also produced subtle changes in the rate of desensitization in response to GABA. Isoflurane enhanced GABA-induced respo...Continue Reading

References

Apr 10, 1992·European Journal of Pharmacology·S H ZamanE A Barnard
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J YangC F Zorumski
Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
May 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M NakahiroT Narahashi
Jan 1, 1985·International Review of Neurobiology·K W Miller
Jul 1, 1982·The Journal of Physiology·K KusanoJ Stinnakre
Jul 20, 1981·Biochimica Et Biophysica Acta·R A SmithK W Miller
Feb 17, 1994·Nature·N P Franks, W R Lieb
Nov 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R A HarrisT K Machu
Jan 28, 1993·Nature·M Farrant, S Cull-Candy
Apr 1, 1993·Journal of Neurochemistry·L H LinR A Harris
Jul 1, 1993·British Journal of Anaesthesia·A Angel
Apr 1, 1993·Anesthesiology·D L TanelianM B MacIver
Apr 1, 1996·Trends in Neurosciences·R M McKernan, P J Whiting
Feb 1, 1996·British Journal of Pharmacology·S A ThompsonK A Wafford
Nov 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R SincoffJ Z Yeh

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Citations

Jul 24, 2001·Anesthesiology·W SimonG Rammes
Aug 28, 2004·Molecular Pharmacology·Hua-Jun Feng, Robert L Macdonald
Jul 13, 2004·Molecular Pharmacology·Hua-Jun FengRobert L Macdonald
Nov 8, 2005·The Journal of Pharmacology and Experimental Therapeutics·Cecilia M BorgheseR Adron Harris
May 21, 2004·Journal of Neurophysiology·Hua-Jun Feng, Robert L Macdonald
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·R A Harris, S J Mihic
Jan 15, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Cam Ha T Tran, Grant R Gordon
Mar 6, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kellie A WollRoderic G Eckenhoff
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·T YamakuraR A Harris

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