Modulation of Reelin signaling by Cyclin-dependent kinase 5

Brain Research
Toshio OhshimaK Mikoshiba

Abstract

The Reelin signaling and Cyclin-dependent kinase 5 (Cdk5) both regulate neuronal positioning in the developing brain. Using double-transgenic mice, we have previously shown that these two signaling pathways lie in parallel fashion and have a genetic interaction. Disabled-1 (Dab1), an adapter protein, mediates Reelin signaling and becomes tyrosine-phosphorylated on the binding of Reelin to its receptors. Several isoforms of Dab1 are expressed in embryonic mouse brain, and p80 [Dab1(555)] is the major protein translated. In the present study, we investigated whether Cdk5-mediated phosphorylation of Dab1 modulates Reelin signaling. Cdk5 phosphorylates p80 Dab1 at multiple sites in its carboxyl-terminal region, and tyrosine phosphorylation of p80 Dab1 by Fyn tyrosine kinase is attenuated by this Cdk5-mediated phosphorylation in vitro. Tyrosine phosphorylation of p80 Dab1 induced by exogenous Reelin is enhanced in Cdk5-deficient neurons, corroborating the inhibitory effect of Cdk5-mediated Ser/Thr phosphorylation on tyrosine phosphorylation of p80 Dab1. Another isoform, p45 Dab1 [Dab1(271)], however, is phosphorylated by Cdk5 at one serine residue within a unique carboxyl-terminal region, and its serine phosphorylation enhances tyro...Continue Reading

References

Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T OhshimaA B Kulkarni
May 10, 2000·Current Biology : CB·R Homayouni, T Curran
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·T OhshimaK Mikoshiba
Mar 30, 2001·The Journal of Biological Chemistry·L KeshvaraT Curran
Aug 25, 2001·Annual Review of Neuroscience·D S Rice, T Curran
Aug 25, 2001·Annual Review of Neuroscience·M E Ross, C A Walsh
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·R Dhavan, L H Tsai
Aug 9, 2002·The Journal of Biological Chemistry·Edwin J WeeberJoachim Herz
Sep 6, 2002·Molecular and Cellular Neurosciences·Kanehiro HayashiKatsuhiko Mikoshiba
Oct 12, 2002·The Journal of Biological Chemistry·Uwe BeffertJoachim Herz
Nov 14, 2002·Molecular Neurobiology·Toshio Ohshima, Katsuhiko Mikoshiba
Jan 16, 2003·Current Biology : CB·Lionel ArnaudJonathan A Cooper
Jan 16, 2003·Current Biology : CB·Hans H Bock, Joachim Herz
Dec 4, 2003·Molecular and Cellular Biology·Lionel ArnaudJonathan A Cooper
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Uwe BeffertJoachim Herz
Apr 2, 2004·The EMBO Journal·Sachin Katyal, Roseline Godbout

❮ Previous
Next ❯

Citations

Feb 18, 2009·Anatomical Science International·Tatsuro YamamotoToshio Terashima
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam J FunkJames H Meador-Woodruff
Oct 23, 2010·Molecular Brain·Karalee K Shideler, Jun Yan
Apr 28, 2010·PloS One·Koji TsutsumiShin-ichi Hisanaga
May 24, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Lin ChengLei Lei
Dec 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yutaka SatoShin-ichi Hisanaga
Mar 20, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takahiro FuchigamiShin-ichi Hisanaga
May 28, 2009·Journal of Neuroscience Research·Weijiang DongSimona Vuletic
Jul 26, 2016·Frontiers in Cellular Neuroscience·Hans H Bock, Petra May
Oct 18, 2020·Molecular and Cellular Neurosciences·Giovanna CeniniOliver Brüstle
Mar 25, 2009·Brain Research Reviews·Eleni Dicou
Nov 30, 2010·Cellular Signalling·Zhihua Gao, Roseline Godbout

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.