Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat

Lipids
Deepa SankaranH M Aukema

Abstract

Low-fat diets and diets containing n-3 fatty acids (FA) slow the progression of renal injury in the male Han:Sprague-Dawley (SPRD)-cy rat model of polycystic kidney disease. To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female pcy mice to examine the effects of fat level and type on disease progression. Adult pcy mice were fed 4, 10, or 20 g soybean oil/100 g diet for 130 d in study 1. In study 2, weanling pcy mice were fed high or low levels of fat rich in 18:2n-6 (corn oil, CO), 18:3n-3 (flaxseed oil/CO 4:1 g/g, FO), or 22:6n-3 (algal oil/CO 4:1 g/g, DO) for 8 wk. In adult pcy mice, low- compared with high-fat diets lowered kidney weights (2.4 +/- 0.2 vs. 3.1 +/- 0.2 g/100 g body weight, P = 0.006) and serum urea nitrogen (SUN) (9.6 +/- 0.6 vs. 11.9 +/- 0.6 mmol/L, P = 0.009), whereas in young pcy mice it reduced renal fibrosis volumes (0.44 +/- 0.04 vs. 0.62 +/- 0.04 mL/kg body weight, P < 0.0001). FO feeding in young pcy mice mitigated the detrimental effects of high fat on fibrosis while not altering kidney size, function, and oxidative damage when compared with the CO-fed mice. In contrast, DO- compared with CO-fed mi...Continue Reading

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Citations

Jul 12, 2007·Nephron. Experimental Nephrology·Deepa SankaranHarold M Aukema
Jun 15, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stephanie P B CaligiuriHarold M Aukema
Sep 30, 2008·Journal of Applied Toxicology : JAT·Xiaolei JinRekha Mehta
Mar 18, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jessay G DevassyHarold M Aukema
Jan 13, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jessay G DevassyHarold M Aukema
Mar 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven CooperK Barry Delclos
Aug 14, 2019·The British Journal of Nutrition·Afroza FerdouseHarold M Aukema
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Marijn F StokmanAlexandre Benmerah
Jun 12, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Avery L PennerHarold M Aukema

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