PMID: 9446695Apr 4, 1998Paper

Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat

Pflügers Archiv : European journal of physiology
H OnimaruI Homma

Abstract

Effects of 5-hydroxytryptamine (5-HT) on inspiration-related nerve activity and membrane potential of respiratory neurons in the ventrolateral medulla were studied in brainstem-spinal cord preparations isolated from newborn rats. Bath application of 5-100 microM 5-HT induced a biphasic response in inspiratory nerve activity: a transient increase in respiratory frequency followed by a decrease in the rate of discharge. The excitatory effect of 5-HT was particularly prominent in preparations with a respiratory rate of less than 3 min-1, whereas the inhibitory effect was more pronounced in preparations with a higher respiratory rate. In pre-inspiratory (Pre-I) and inspiratory (Insp) neurons, 20 microM 5-HT induced a membrane depolarization of up to 10 mV accompanied by a significant decrease in the input resistance. Membrane depolarization by 5-HT was also evident in the presence of tetrodotoxin. In Pre-I neurons, 5-HT caused an increase in the burst rate, which was followed by a decrease in the intraburst firing frequency and burst amplitude, although the burst rate remained high. The burst rate in Insp neurons first increased and subsequently decreased without significant change in the intraburst firing frequency. Simultaneous i...Continue Reading

Citations

Jun 8, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Suguru KobayashiMamoru Aoki
Sep 15, 2010·Journal of Computational Neuroscience·Natalia Toporikova, Robert J Butera
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Nov 12, 2002·Respiratory Physiology & Neurobiology·Olivier BelzileRichard Kinkead
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