Modulation of Rho GTPases by type III secretion system translocated effectors of Yersinia

Reviews of Physiology, Biochemistry and Pharmacology
Martin Aepfelbacher

Abstract

Pathogenic species of the bacterial genus Yersinia subdue the immune system to proliferate and spread within the host organism. For this purpose yersiniae employ a type III secretion apparatus which governs injection of six effector proteins ( Y ersinia outer proteins; Yops) into host cells. Yops control various regulatory and signalling proteins in a unique and highly specific manner. YopE, YopT, and YpkA/YopO modulate the activity of Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins. Furthermore, YopP/YopJ and YopM affect cell survival/apoptosis and cell proliferation, respectively. In this review the focus will be on the biochemistry and cellular effects of YopT, YopE, YopO/YpkA, and YopH.

Citations

Oct 16, 2007·Clinical Microbiology Reviews·Bryan CoburnB Brett Finlay
Apr 26, 2005·Annual Review of Microbiology·Gloria I Viboud, James B Bliska
Aug 16, 2005·Cellular Microbiology·C Erec Stebbins
Feb 12, 2011·International Journal of Biological Macromolecules·O Krishnadev, N Srinivasan
May 29, 2007·Molecular Cell·Lorena NavarroJack E Dixon

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