Modulation of secondary antibody response in SRBC-immunized mice by lysozyme dimer

Immunopharmacology and Immunotoxicology
B Obmińska-DomoradzkaJ Debowy

Abstract

The effect of lysozyme dimer (20 micrograms/kg) injected i.p. once or four times to sheep erythrocytes-immunized mice on the secondary humoral response was studied with respect to the time of exposure to the drug in relation to priming and challenge. It has been found that lysozyme dimer potentiates secondary humoral response to SRBC; as a result, the number of splenocytes producing hemolytic anti-SRBC antibodies (PFC) and anti-SRBC hemagglutinin titers, especially 2-mercaptoethanol resistant increases provided that the drug is administered after the challenge. Lysozyme dimer (both a single dose and four times' exposure to the drug) administered after priming does not affect secondary humoral response of SRBC-immunized mice.

References

Dec 1, 1990·Immunology Today·T HiranoT Kishimoto
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R D GarmanD H Raulet
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Jul 1, 1984·Immunology Today·R J Robb

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