Modulation of serum parathyroid hormone and ionized calcium concentrations during reproduction in rats fed a low calcium diet

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
S C GarnerS U Toverud

Abstract

Moderate dietary restriction of calcium (0.1% Ca) was used to accentuate the changes in serum immunoreactive parathyroid hormone (iPTH) that had been reported earlier in lactating rats fed 0.4% Ca diet. In addition, the effects of this low-Ca diet on serum total and ionized Ca and iPTH during pregnancy, extended lactation, and weaning were examined. The positive correlation between serum total and ionized Ca was highly significant (r = 0.88, p less than 0.001, n = 120). Serum iPTH was significantly higher (36%) in pregnant rats on the day of parturition compared to nonmated controls, and there was a concomitant decrease in both total and ionized serum Ca. Within 1 day after parturition, however, serum Ca had risen to the control level. Serum iPTH remained significantly elevated during the first 2 weeks of lactation, and increased further during the third week of lactation to a level more than twice that of nonlactating controls. Serum Ca fell gradually during the second week of lactation. The high serum iPTH levels were maintained for another 2 weeks when lactation was extended with foster litters. Within 6 hr of removal of the suckling pups on day 16 of lactation, maternal serum ionized and total Ca had risen and serum iPTH ha...Continue Reading

References

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Citations

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J Verhaeghe, R Bouillon
Feb 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T C PengR P Kusy
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C GarnerS U Toverud
Oct 27, 2018·Journal of Bone and Mineral Metabolism·Ryan D RossD Rick Sumner
Jan 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S C GarnerS U Toverud
Jun 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V L SchultzS U Toverud
Dec 31, 1997·Endocrine Reviews·C S Kovacs, H M Kronenberg
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M E WlodekJ M Moseley
Sep 25, 2003·Alcoholism, Clinical and Experimental Research·Kathy Keiver, Joanne Weinberg
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Ronald L HorstTimothy A Reinhardt

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