Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats.

International Journal of Endocrinology
Ricardo Borges MachadoDeborah Suchecki

Abstract

Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of the present study was to evaluate how manipulations of the CRH system during the sleep deprivation period interferes with subsequent sleep rebound. Throughout 96 hours of sleep deprivation, separate groups of rats were treated i.c.v. with vehicle, CRH or with alphahelical CRH(9-41), a CRH receptor blocker, twice/day, at 07:00 h and 19:00 h. Both treatments impaired sleep homeostasis, especially in regards to length of rapid eye movement sleep (REM) and theta/delta ratio and induced a later decrease in NREM and REM sleep and increased waking bouts. These changes suggest that activation of the CRH system impact negatively on the homeostatic sleep response to prolonged forced waking. These results indicate that indeed, activation of the HPA axis-at least at the hypothalamic level-is capable to reduce the sleep rebound induced by sleep deprivation.

References

Oct 1, 1978·Electroencephalography and Clinical Neurophysiology·L K GerbrandtR L Lloyd
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K R Melia, R S Duman
May 27, 1991·Neuroscience Letters·C RampinM Jouvet
Jan 1, 1991·Psychopharmacology·H A BaldwinK T Britton
May 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J BornH L Fehm
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·J T WinslowT R Insel
May 1, 1986·Experimental Eye Research·C W JonesO Jonasson
Oct 1, 1985·Physiology & Behavior·A M Coenen, E L van Luijtelaar
Dec 1, 1985·Behavioural Brain Research·S Grahnstedt, R Ursin
Sep 1, 1970·Physiology & Behavior·C Timo-IariaT Leme da Rocha
Nov 1, 1984·Physiology & Behavior·E L van Luijtelaar, A M Coenen
Jul 1, 1995·Behavioural Brain Research·A Rechtschaffen, B M Bergmann
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·T KishimotoM G Rosenfeld
Oct 31, 1994·Annals of the New York Academy of Sciences·F MenzaghiG F Koob
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Sep 1, 1993·Physiology & Behavior·R E Adamec, D McKay
Nov 1, 1995·Neuroscience and Behavioral Physiology·O S VinogradovaV F Kichigina
Jan 1, 1997·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K D DieterichE B De Souza
May 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·A V Turnbull, C Rivier
Mar 28, 1997·Neuroscience Letters·P MeerloS Daan
Jun 1, 1997·Archives of Disease in Childhood·P N Malleson
May 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·P Fadda, W Fratta
May 8, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M L PriceI Lucki

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Citations

May 15, 2013·PloS One·Ricardo Borges MachadoDeborah Suchecki
Sep 4, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Irma GviliaRonald Szymusiak
Jan 10, 2017·Frontiers in Endocrinology·Ricardo Borges Machado, Deborah Suchecki
Aug 4, 2016·Behavioral Sleep Medicine·Margaret H BublitzLaura R Stroud

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