Modulation of solitarial deglutitive N-methyl-D-aspartate receptors by dihydropyridines.

Neuropharmacology
M A HashimD Bieger

Abstract

The ability of the dihydropyridine calcium channel activators, (-)-S-BAY K 8644 and (+)-S-202-791 and the calcium channel inhibitor, (+)-R-BAY K 8644, to modify the differential deglutitive actions of glutamate and muscarine at premotor loci in the nucleus tractus solitarii was investigated in urethane-anaesthetised rats. At subnuclei ventralis and intermedialis loci, pneumophoretic application (20-100 pl) from multibarrelled glass micropipettes (tip diameter 2-5 microns) of glutamate (10-20 pmol) evoked aminophosphonovaleric acid (APV)-insensitive pharyngeal swallows; at sites in the subnucleus centralis of the nucleus tractus solitarii glutamate evoked an APV-sensitive single-wave oesophageal response, whereas muscarine (5-10 pmol) evoked rhythmic oesophageal contractions. Both (-)-S-BAY K 8644 and (+)-S-202-791, applied in prepulses of 10-20 fmol and 100-200 fmol, respectively, either had no effect or selectively and reversibly enhanced or inhibited the glutamate-evoked responses. Identical results were obtained by intravenous administration of (-)-S-BAY K 8644 (10-50 micrograms/kg). Micropneumophoretic (20-50 fmol) or intravenous (10-50 micrograms/kg) administration of (+)-R-BAY K 8644 suppressed the N-methyl-D-aspartate (N...Continue Reading

References

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Citations

Dec 26, 2001·The American Journal of Medicine·R H Holloway
Dec 1, 2001·European Journal of Pharmacology·A Lehmann, L Brändén
Nov 7, 1998·Biochimica Et Biophysica Acta·S H White, W C Wimley
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Jul 23, 2008·Developmental Disabilities Research Reviews·Arthur J Miller
Jan 14, 2005·Gastroentérologie Clinique Et Biologique·Thierry Piche

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