Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle

The Journal of Nutritional Biochemistry
Diana N ObandaWilliam T Cefalu

Abstract

This study sought to investigate the effect of calorie restriction (CR) on skeletal muscle sphingolipid metabolism and its contribution to improved insulin action in rats after a 6-month feeding study. Twenty nine (29) male Fischer 344 rats were randomized to an ad libitum (AL) diet or 30% CR. Dietary intake, body weight and insulin sensitivity were monitored. After 6 months, skeletal muscle (vastus lateralis) was obtained for insulin signaling and lipid profiling. CR significantly decreased insulin and glucose levels and also altered the expression and activity of proteins involved in sphingolipid formation and metabolism. The quantities of ceramides significantly increased in CR animals (P<.05; n=14-15), while ceramide metabolism products (i.e., glycosphingolipids: hexosylceramides and lactosylceramides) significantly decreased (P<.05; n=14-15). Ceramide phosphates, sphingomyelins, sphingosine and sphingosine phosphate were not significantly different between AL and CR groups (P=ns; n=14-15). Lactosylceramide quantities correlated significantly with surrogate markers of insulin resistance (homeostasis model of assessment on insulin resistance) (r=0.7; P<.005). Products of ceramide metabolism (glycosphingolipids), known to int...Continue Reading

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Mar 14, 2013·The Journal of Nutritional Biochemistry·Diana N Obanda, William T Cefalu

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Citations

Sep 6, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Haiyan WangGregory D Cartee
Oct 3, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kentaro OkiGregory D Cartee
Nov 15, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Sep 25, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Piao ShenghuaGuo Jiao

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