Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models

Frontiers in Computational Neuroscience
Alexandre FoncelleLaurent Venance

Abstract

In spike-timing dependent plasticity (STDP) change in synaptic strength depends on the timing of pre- vs. postsynaptic spiking activity. Since STDP is in compliance with Hebb's postulate, it is considered one of the major mechanisms of memory storage and recall. STDP comprises a system of two coincidence detectors with N-methyl-D-aspartate receptor (NMDAR) activation often posited as one of the main components. Numerous studies have unveiled a third component of this coincidence detection system, namely neuromodulation and glia activity shaping STDP. Even though dopaminergic control of STDP has most often been reported, acetylcholine, noradrenaline, nitric oxide (NO), brain-derived neurotrophic factor (BDNF) or gamma-aminobutyric acid (GABA) also has been shown to effectively modulate STDP. Furthermore, it has been demonstrated that astrocytes, via the release or uptake of glutamate, gate STDP expression. At the most fundamental level, the timing properties of STDP are expected to depend on the spatiotemporal dynamics of the underlying signaling pathways. However in most cases, due to technical limitations experiments grant only indirect access to these pathways. Computational models carefully constrained by experiments, allow ...Continue Reading

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Citations

Jul 23, 2019·Cerebral Cortex·Giuseppe GangarossaLaurent Venance
May 10, 2020·PLoS Computational Biology·Lisandro MontangieJulijana Gjorgjieva
Aug 10, 2019·Frontiers in Cellular Neuroscience·Junxiu LiuDavid M Halliday
Dec 21, 2019·Scientific Reports·Teresa Morera-HerrerasLaurent Venance
Nov 3, 2020·Frontiers in Systems Neuroscience·Andrea MatteraGianluca Baldassarre
Jun 30, 2021·Nature Communications·Jan H Kirchner, Julijana Gjorgjieva
Aug 26, 2021·Journal of Computational Neuroscience·Joseph T Schmalz, Gautam Kumar

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