Modulation of splanchnic circulation: Role in perioperative management of liver transplant patients

World Journal of Gastroenterology : WJG
Ahmed Mukhtar, Hany Dabbous

Abstract

Splanchnic circulation is the primary mechanism that regulates volumes of circulating blood and systemic blood pressure in patients with cirrhosis accompanied by portal hypertension. Recently, interest has been expressed in modulating splanchnic circulation in patients with liver cirrhosis, because this capability might produce beneficial effects in cirrhotic patients undergoing a liver transplant. Pharmacologic modulation of splanchnic circulation by use of vasoconstrictors might minimize venous congestion, replenish central blood flow, and thus optimize management of blood volume during a liver transplant operation. Moreover, splanchnic modulation minimizes any high portal blood flow that may occur following liver resection and the subsequent liver transplant. This effect is significant, because high portal flow impairs liver regeneration, and thus adversely affects the postoperative recovery of a transplant patient. An increase in portal blood flow can be minimized by either surgical methods (e.g., splenic artery ligation, splenectomy or portocaval shunting) or administration of splanchnic vasoconstrictor drugs such as Vasopressin or terlipressin. Finally, modulation of splanchnic circulation can help maintain perioperative ...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A HadengueD Lebrec
Jan 1, 1982·Annual Review of Physiology·P D Richardson, P G Withrington
Jun 1, 1982·The American Journal of Physiology·T D BennettC F Rothe
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kevin P MooreVicente Arroyo
Jun 8, 2004·Scandinavian Journal of Gastroenterology·M Kiszka-KanowitzF Bendtsen
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Rebecca A SchroederPaul C Kuo
Sep 17, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen
Oct 19, 2004·Anaesthesia·P C A KamF F Y Yoong
May 10, 2005·Regulatory Peptides·Angelita Polato SchmeischAdelar Bracht
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Roberto TroisiBernard de Hemptinne
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Taketoshi SuehiroHiroyuki Kuwano
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Felix DahmPierre-Alain Clavien
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luc MassicotteAndré Roy
Feb 9, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M GlanemannP Neuhaus
Mar 11, 2006·Kidney International·J B CabezueloP Parrilla
Jul 25, 2006·The American Journal of Surgical Pathology·Anthony J DemetrisAmadeo Marcos
Nov 30, 2006·Critical Care Medicine·Lucinda K BarrettLucie H Clapp
Mar 29, 2007·Gut·Francesco SalernoVicente Arroyo
Sep 4, 2007·Journal of Gastroenterology and Hepatology·Hui-Chun HuangShou-Dong Lee
Nov 21, 2007·Hemodialysis International·Rajesh YalavarthyIsaac Teitelbaum
Dec 15, 2007·Critical Care : the Official Journal of the Critical Care Forum·Vladimir KrejciGisli H Sigurdsson
Feb 29, 2008·Journal of Hepatology·Paolo Angeli, Carlo Merkel
May 7, 2008·Current Opinion in Anaesthesiology·Yves Ozier, John R Klinck
Jun 10, 2008·Pharmacology & Therapeutics·P A McCormick, Carmel Donnelly
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gebhard WagenerDonald Landry
Feb 10, 2009·Postgraduate Medical Journal·Francesco SalernoVicente Arroyo
Apr 29, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yousri M BarriGoran B Klintmalm
Jun 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard A MermelDavid K Warren
Aug 19, 2009·Journal of Gastroenterology and Hepatology·Yoshiyuki NaraharaChoitsu Sakamoto
Nov 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lise L GluudAleksander Krag
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Constantino FondevilaJuan C García-Valdecasas
Sep 24, 2011·Hepato-gastroenterology·Zuhai RenShaihong Zhu
Dec 1, 2011·Intensive Care Medicine·Angelo PolitoDjillali Annane
Oct 11, 2012·World Journal of Gastroenterology : WJG·Jan Lata
Dec 12, 2012·Clinical Physiology and Functional Imaging·Darija BakovicZeljko Dujic
Mar 1, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Garrett R RollJohn Paul Roberts

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Citations

Mar 16, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mettu Srinivas ReddyMohamed Rela
Jun 16, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sunil Taneja, Yogesh K Chawla
Mar 27, 2018·Acta Anaesthesiologica Scandinavica·E WisénS-E Ricksten
May 2, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Siyuan YaoShinji Uemoto
Mar 10, 2018·Annals of Surgical Treatment and Research·Dong-Sik KimJu Young Kim
Jun 23, 2018·World Journal of Gastroenterology : WJG·Xiang LanBo Li
Apr 21, 2019·Journal of Clinical Monitoring and Computing·Ahmed M MukhtarAmr A Abdelaal

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