PMID: 15357003Sep 11, 2004Paper

Modulation of suppressive activity of lipopolysaccharide-induced nitric oxide production by glycosidation of flavonoids

Archives of Pharmacal Research
Yong Soo KwonWanjoo Chun

Abstract

Flavonoids have been demonstrated to exhibit a wide range of biological activities including anti-inflammatory and neuroprotective actions. Although a significant amount of flavonoids has been identified to be present as glycosides in medicinal plants, determinations of the biological activities of flavonoids were mainly carried out with aglycones of flavonoids. Therefore, the exact role of the glycosidation of flavonoid aglycones needs to be established. In an attempt to understand the possible role of glycosidation on the modulation of the biological activities of flavonoids, diverse glycosides of kaempferol, quercetin, and aromadendrin were examined in terms of their anti-inflammatory activity determined with the suppression of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV2 microglial cells. The results indicated that glycosidation of aglycones attenuated the suppressive activity of aglycones on LPS-induced NO production. Although attenuated, some of glycosides, depending on the position and degree of glycosidation, maintained the inhibitory capability of LPS-induced NO production. These findings suggest that glycosidation of flavonoid aglycones should be considered as an important modulator of the biol...Continue Reading

References

Apr 1, 1992·Journal of Neuroscience Research·V BocchiniH Kettenmann
Apr 1, 1983·Biochemical Pharmacology·B Havsteen
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
May 13, 1999·Biochimica Et Biophysica Acta·M P Murphy
Feb 15, 2001·Journal of Natural Products·B Y HwangJ J Lee
Jun 22, 2002·Annals of the New York Academy of Sciences·Bin LiuJau-Shyong Hong
Oct 10, 2002·Chemical & Pharmaceutical Bulletin·Chikako MasuokaToshihiro Nohara

❮ Previous
Next ❯

Citations

Jun 14, 2012·Natural Product Research·Alessandro VendittiArmandodoriano Bianco
Jun 23, 2009·Expert Opinion on Drug Safety·Bernardino OssolaPekka T Männistö
Oct 16, 2015·Critical Reviews in Food Science and Nutrition·Jianbo XiaoAnca Miron
May 2, 2014·Biotechnology Advances·Jianbo XiaoMilen I Georgiev
Jul 16, 2015·Critical Reviews in Food Science and Nutrition·Jianbo Xiao
Mar 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun Ju JeongYoung Choong Kim
May 27, 2014·Biotechnology Advances·Jianbo XiaoHui Cao
Sep 2, 2006·Biological & Pharmaceutical Bulletin·Runping LiQuan Li
Jul 9, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Guohua AnMarilyn E Morris
Aug 6, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xiaodong WangMarilyn E Morris
Aug 18, 2020·Journal of Clinical Biochemistry and Nutrition·Hisae OkuKyoko Ishiguro
Feb 2, 2021·Frontiers in Pharmacology·Jéssica Silva Dos SantosManoela Marques Ortega
Oct 10, 2021·Journal of the Science of Food and Agriculture·Ke ZhaoHongfei Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.