Modulation of sustained and transient lateral inhibitory mechanisms in the mudpuppy retina during light adaptation

Journal of Neurophysiology
P B Cook, J S McReynolds

Abstract

Two functionally and anatomically distinct types of lateral inhibition contribute to the receptive field organization of ganglion cells in the vertebrate retina: sustained lateral inhibition (SLI), which is present during steady illumination and transient lateral inhibition (TLI), evoked by changes in illumination. We studied adaptive changes in these two lateral inhibitory mechanisms in the mudpuppy retina by measuring the responses of ON-OFF ganglion cells to spots of light in the receptive field center, in the absence and presence of a concentric broken annulus (windmill) pattern, which was either stationary or rotating. SLI was measured as the percent suppression of the centered spot response by the stationary windmill and TLI was measured as the additional suppression produced when the windmill was rotating. In dark-adapted retinas SLI was elicited by windmills of 600 or 1,200 micron ID, but TLI could not be elicited by windmills of any size, over a wide range of windmill intensities and rotation rates. Exposure of dark-adapted retinas to diffuse adapting light caused an immediate decrease in the response to the spot alone, followed by slowly developing changes in both SLI and TLI: SLI produced by 1,200 micron ID windmills...Continue Reading

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Citations

Apr 10, 1999·Nature Neuroscience·P B Cook, J S McReynolds
Mar 4, 2003·Journal of Neurophysiology·Colleen R Shields, Peter D Lukasiewicz
Mar 12, 2005·The Journal of Physiology·Tomomi Ichinose, Peter D Lukasiewicz
Mar 6, 2002·Journal of Neurophysiology·Alexander O Komendantov, Carmen C Canavier
Mar 1, 2005·Visual Neuroscience·Jun ZhangChen-Yu Yang
Dec 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S LandiM C Cenni
Sep 24, 2005·Journal of Integrative Neuroscience·Soh HidakaYoko Hashimoto
Sep 15, 2020·Frontiers in Cellular Neuroscience·Chase B HellmerTomomi Ichinose
Aug 10, 2000·Neural Computation·R M Balboa, N M Grzywacz

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