Modulation of sympathetic preganglionic neuron activity via adrenergic receptors

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yoshino MinouraYouichi Kobayashi

Abstract

The sympathetic preganglionic neurons (SPNs) play a key role in the sympathetic nervous system. Previous reports have suggested that norepinephrine (NE) directly affects SPNs via both inhibitory hyperpolarization interactions mediated by α2 receptors and excitatory depolarization interactions mediated by α1 receptors. It remains poorly understood, however, whether the excitability of SPNs can be inhibited indirectly (presynaptically) as well as directly (postsynaptically). We intracellularly recorded 41 SPNs using the whole-cell patch-clamp technique in spinal cord slice preparations of neonatal rats. We examined the effects of NE or dexmedetomidine hydrochloride (Dxm) (α2-adrenergic receptor agonist) on SPNs by analyzing the excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs). EPSPs were dominant in 15 SPNs (EPSP-SPNs) and IPSPs were dominant in 7 SPNs (IPSP-SPNs) at baseline. We were unable to analyze the postsynaptic potentials in the other 19 SPNs, due to high frequency of action potential firings (firing-SPNs). At baseline, the membrane potentials and resistances of each type of SPN were similar. NE (1  μM) gradually depolarized the EPSP-SPNs and IPSP-SPNs (P   < 0.001) and NE signific...Continue Reading

References

Dec 5, 1975·Brain Research·J A ZivinI J Kopin
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Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lihua WangSusan A Deuchars
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshino MinouraYouichi Kobayashi
Nov 16, 2012·Autonomic Neuroscience : Basic & Clinical·Ayaka TanabeIkuo Homma
Jun 26, 2015·Journal of Neurophysiology·Mariho TaniHiroshi Onimaru

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Citations

Jul 13, 2019·Bioinformatics·Jakub M BartoszewiczBernhard Y Renard

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