Modulation of synaptic activity in Purkinje neurons by ATP

The Cerebellum
Joachim W DeitmerDiana Casel

Abstract

Adenosine triphosphate (ATP) is a versatile signalling molecule in the central and peripheral nervous system, where it can be released from both neurons and glial cells. In the cerebellum, ATP is released endogenously from the second postnatal week onwards, and is involved in the up-regulation of spontaneous synaptic input to Purkinje neurons by activation of purinergic P2 receptors. In the cerebellar cortex, ATP presumably acts on presynaptic inhibitory interneurons, which are excited by the activation of both P2X and P2Y receptors. P2 receptors have been reported for Purkinje neurons, where they mediate intracellular Ca(2+) responses. The extracellular concentration of ATP is modulated by its enzymatic degradation by ecto-nucleotidases. Adenosine, which modulates evoked transmitter release, does not influence the spontaneous synaptic activity in Purkinje neurons. Some implications of ATP as a tonically active neuromodulator in the cerebellum are discussed.

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Citations

Aug 10, 2010·The Cerebellum·Raphaël CourjaretJoachim W Deitmer
Nov 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jason R Pugh, Craig E Jahr
May 21, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peter J S SmithMark A Messerli
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Mar 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael DoengiChristian Lohr
Nov 19, 2019·Frontiers in Neuroscience·Jen-Hsiang T HsiaoWoojin Scott Kim
Sep 21, 2021·Frontiers in Cell and Developmental Biology·María Berenice Soria-OrtizDaniel Reyes-Haro

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