Modulation of synaptic transmission by dopamine and norepinephrine in ventral but not dorsal striatum

Journal of Neurophysiology
S M Nicola, R C Malenka

Abstract

Although the ventral striatum (nucleus accumbens; NAc) and dorsal striatum are associated with different behaviors, these structures are anatomically and physiologically similar. In particular, dopaminergic afferents from the midbrain appear to be essential for the normal functioning of both nuclei. Although a number of studies have examined the effects of dopamine on the physiology of NAc or striatal cells, results have varied, and few studies have compared directly the actions of dopamine on both of these nuclei. Here we use slice preparations of the NAc and dorsal striatum to compare how synaptic transmission in these nuclei is modulated by catecholamines. As previously reported, dopamine depressed excitatory postsynaptic potentials (EPSPs) and inhibitory postsynaptic potentials (IPSPs) in the NAc. Surprisingly, however, neither EPSPs nor IPSPs in the dorsal striatum were affected by dopamine. Similarly, norepinephrine depressed excitatory synaptic transmission in the NAc by an alpha-adrenergic receptor-dependent mechanism but was without effect on excitatory transmission in the dorsal striatum. Inhibitory synaptic transmission was not affected by norepinephrine in either structure. These results suggest that the functional ...Continue Reading

References

Sep 3, 1976·Brain Research·D H VersteegM Palkovits
Jul 11, 1975·Brain Research·L W Swanson, W M Cwan
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D J SurmeierS T Kitai
Jul 1, 1990·Trends in Neurosciences·P S Goldman-Rakic, L D Selemon
Jul 1, 1990·Trends in Neurosciences·A Parent
Jan 1, 1991·Physiological Reviews·M Le Moal, H Simon
Jan 8, 1985·The Journal of Comparative Neurology·L S JonesJ N Davis
Dec 1, 1985·Journal of Neurophysiology·J F DeFranceR B Chronister
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jul 1, 1983·Neuropharmacology·S W JohnsonR Freedman
Aug 1, 1995·The European Journal of Neuroscience·P CalabresiG Bernardi
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C CepedaM S Levine
Sep 23, 1994·Science·A M GraybielM Kimura
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·L S SeidenG A Ricaurte
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·J T IsaacR C Malenka
Oct 6, 1997·Journal of Neurophysiology·M Umemiya, L A Raymond

❮ Previous
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Citations

Jul 23, 1999·Annals of the New York Academy of Sciences·P O'DonnellA A Grace
May 7, 2004·The European Journal of Neuroscience·Elizabeth Hernández-EcheagarayMichael S Levine
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David Weinshenker, Jason P Schroeder
Jan 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marcello D'AscenzoPhilip G Haydon
May 14, 2016·Journal of Neurophysiology·Andrea L Gutman, Sharif A Taha
Jul 6, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carolyn G SweeneyHaley E Melikian
Aug 13, 1999·Journal of Neurophysiology·A Y HsiaP M Lledo
Feb 18, 2005·Brain : a Journal of Neurology·Philippe RemyDavid Brooks
Nov 4, 2004·Journal of Receptor and Signal Transduction Research·Kim A NeveHeather Trantham-Davidson
May 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Henry H Yin, David M Lovinger
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Charara, A A Grace
May 25, 2007·Journal of Neurophysiology·Nanping WuMichael S Levine
Apr 8, 2011·Annual Review of Neuroscience·Charles R Gerfen, D James Surmeier
May 26, 2012·Developmental Neuroscience·Carlos Cepeda, Michael S Levine
Oct 13, 2006·Neurochemical Research·Elizabeth Hernández-EcheagarayMichael S Levine
Jun 9, 2000·Annual Review of Neuroscience·S M NicolaR C Malenka
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Oct 1, 2004·Journal of Neurophysiology·Stefano TavernaCyriel M A Pennartz
May 16, 2001·Journal of Neurophysiology·J S FitzpatrickJ P Walsh
Dec 6, 2002·Journal of Neurophysiology·Jorge Flores-HernándezMichael S Levine
Oct 27, 2004·Cell and Tissue Research·Saleem M NicolaGregory O Hjelmstad
Aug 18, 2004·British Journal of Pharmacology·Carl R LupicaAlexander F Hoffman
May 4, 2006·Science's STKE : Signal Transduction Knowledge Environment·Carlos Cepeda, Michael S Levine
Oct 28, 2019·The Lancet Child & Adolescent Health·Nigel S Bamford, Kathryn McVicar
Jun 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Daniel J ChristoffelRobert C Malenka
Nov 28, 2009·Progress in Neurobiology·Mark D Humphries, Tony J Prescott
Oct 4, 2011·Progress in Neurobiology·Marsha R Penner, Sheri J Y Mizumori

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