PMID: 6982471Sep 1, 1982Paper

Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor

Proceedings of the National Academy of Sciences of the United States of America
E P AmentoS M Krane

Abstract

A human cell line (U937) can be stimulated to produce a soluble factor (MCF) by either lectin-activated T lymphocytes or their soluble products. In prior studies, we showed that MCF produced by peripheral blood mononuclear cells can increase production of collagenase and prostaglandin E2 by adherent synovial cells obtained from enzymatically dispersed rheumatoid synovium. We show here that peripheral blood T lymphocytes or cloned human T lymphocyte lines are capable of inducing MCF production by the monocyte-like U937 cells. MCF can be demonstrated in the supernatant fluid from cocultures of U937 cells and T lymphocytes that have been stimulated with phytohemagglutinin or concanavalin A for 24-48 hr. In addition, the supernatant fluid from 24-hr lectin-stimulated T lymphocytes can be transferred onto the U937 cells and subsequently, MCF activity can be recovered from the U937 culture medium. The activity of the soluble T cell product on the U937 cells is both time- and dose-dependent. A human cell line capable of MCF production in continuous culture has not been previously available. The use of a monocyte-like cell line (U937) and cloned T lymphocytes now makes it possible to demonstrate the role of discrete cell populations in...Continue Reading

References

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Citations

Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SatoS I Murota
Sep 1, 1988·Calcified Tissue International·E IkedaS Yamamoto
Dec 1, 1984·Collagen and Related Research·E D HarrisS M Krane
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K M BrownD L Rosenstreich
Jan 1, 1984·The Journal of Experimental Medicine·Z LiaoD L Rosenstreich
Jan 1, 1990·Annals of the New York Academy of Sciences·S M KraneM B Goldring
Dec 1, 1993·The American Review of Respiratory Disease·J M DayerL P Nicod
Oct 1, 1990·The Journal of Clinical Investigation·D A FoxR W Kinne
Jan 1, 1991·Springer Seminars in Immunopathology·P ResR de Vries
Apr 15, 1985·Experientia·T Kouri
Sep 1, 1983·Cellular Immunology·T Krakauer, J J Oppenheim
Jan 1, 1985·Annals of the New York Academy of Sciences·C L Mainardi
Oct 1, 1985·Clinical Endocrinology·I P Braidman, D C Anderson
Mar 15, 1988·Biochemical and Biophysical Research Communications·J Balsinde, F Mollinedo
Jan 1, 1995·Scandinavian Journal of Immunology·E F Putz, D N Männel
Jun 1, 1983·Annals of the Rheumatic Diseases·D McCarty

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