PMID: 9419016Jan 7, 1998Paper

Modulation of T cell-endothelial adhesion by astrocyte conditioned medium

Glia
J JosephR L Knobler

Abstract

Astrocytes and derived factors maintain the morphologic, phenotypic, and physiological properties of the blood-brain barrier. Astroglial cells may also modulate endothelial cell properties associated with the entry of inflammatory cells into the brain. The study of mechanisms of lymphocyte migration through the blood-brain barrier is critical to understanding the pathophysiology of autoimmune (multiple sclerosis) and virus-induced central nervous system diseases (HIV-induced dementia). In this context the contribution of astrocyte derived factors in regulating the interactions between inflammatory cells and endothelial cells of the blood-brain barrier was studied. The treatment of endothelial cells derived from brain or peripheral sources (hepatic) with astrocyte conditioned medium resulted in a dose dependent enhancement of adhesion of T cells to endothelium. The antigen specificity of the T cells did not influence the findings. Identical results were obtained with fresh Concanavalin A activated T cells and T cell hybridomas generated using myelin basic protein or chicken ovalbumin as immunogens. Further studies are in progress to define the active components in astrocyte conditioned medium and endothelial cell adhesion molecu...Continue Reading

References

Dec 1, 1991·The Journal of Cell Biology·L L RubinJ Morales
Dec 1, 1991·Journal of Neuroimmunology·M M WaldschmidtM N Hart
Mar 1, 1987·Journal of Neuropathology and Experimental Neurology·M N HartP A Cancilla
Feb 1, 1988·The Journal of Experimental Medicine·M P Happ, E Heber-Katz
May 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M A RupnickS K Williams
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jan 1, 1995·Critical Reviews in Clinical Laboratory Sciences·R Martin, H F McFarland

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Citations

Dec 4, 2015·International Journal of Molecular Sciences·Runhong LeiYulin Deng
Oct 19, 2004·Molecular Immunology·Cornelia SpethSieghart Sopper
Aug 29, 2000·Cephalalgia : an International Journal of Headache·P Martelletti, S Morrone

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