Palatable foods lead to overeating, and it is almost a forgone conclusion that it is also an important contributor to the current obesity epidemic - there is even talk about food addiction. However, the cause-effect relationship between taste and obesity is far from clear. As discussed here, there is substantial evidence for altered taste sensitivity, taste-guided liking and wanting, and neural reward processing in the obese, but it is not clear whether such traits cause obesity or whether obesity secondarily alters these functions. Studies with calorie restriction-induced weight loss and bariatric surgery in humans and animal models suggest that at least some of the obesity-induced alterations are reversible and consequently represent secondary effects of the obese state. Thus, both genetic and non-genetic predisposition and acquired alterations in taste and reward functions appear to work in concert to aggravate palatability-induced hyperphagia. In addition, palatability is typically associated with high energy content, further challenging energy balance regulation. The mechanisms responsible for these alterations induced by the obese state, weight loss, and bariatric surgery, remain largely unexplored. Better understanding w...Continue Reading
Effects of degree of obesity, age of onset, and weight loss on responsiveness to sensory and external stimuli
Sensory discrimination, intensity perception, and affective judgment of sucrose-sweetness in the overweight
Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects
Chemosensory dysfunction is a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer
Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons
Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals
Taste acuity of obese adolescents and changes in food neophobia and food preferences during a weight reduction session
Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards
High and low fat food selection with reported frequency intolerance following Roux-en-Y gastric bypass
Gustatory and olfactory sensitivity in patients with anorexia and bulimia in the course of treatment
Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study
Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss
Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies
Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators
Genetic taste blindness to bitter and body composition in childhood: a Mendelian randomization design
"The next mouthful will be the best": influence of prevision of the pleasure on the decision of having a second helping of a just eaten food
Increased intravenous morphine self-administration following Roux-en-Y gastric bypass in dietary obese rats
Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-plant membranes for three months in overweight women
Volitional regulation of brain responses to food stimuli in overweight and obese subjects: A real-time fMRI feedback study
A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption
Impaired taste sensation in type 2 diabetic patients without chronic complications: a case-control study
GLP-1 Analog Modulates Appetite, Taste Preference, Gut Hormones, and Regional Body Fat Stores in Adults with Obesity.
Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity
Reduced dietary intake of simple sugars alters perceived sweet taste intensity but not perceived pleasantness
Alteration Pattern of Taste Perception After Bariatric Surgery: a Systematic Review of Four Taste Domains
Different and Unequal: A Qualitative Evaluation of Salient Factors Influencing Energy Intake in Adults with Overweight and Obesity
Glucagon-Like Peptide 1 and Taste Perception: From Molecular Mechanisms to Potential Clinical Implications.
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