PMID: 7541298Mar 1, 1995Paper

Modulation of tau neuronal expression induced by NMDA, non-NMDA and metabotropic glutamate receptor agonists

Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration
P CouratierJ Hugon

Abstract

We have analysed changes in tau protein immunoreactivity in rat embryonic neurons degenerating in response to treatment with N-methyl-D-aspartate (NMDA), non-NMDA and metabotropic agonists. Glutamate agonists were applied in Mg(++)-free and glycine-supplemented medium 8 days after initial plating. Cell viability was assessed by fluorescein diacetate staining and neuronal survival was evaluated by cell counting. Immunocytochemical and confocal laser microscopic studies used a tau2 monoclonal antibody. Acute and chronic NMDA treatment induced a concentration-dependent increase in intraneuronal tau immunoreactivity. Increased tau immunolabelling during chronic NMDA toxicity was dramatically attenuated by tetrodotoxin and also by 6-cyano-7-nitroquinoxaline-2,3-dione. Non-NMDA and metabotropic receptor agonist treatment produced a weaker augmentation in tau2 immunoreactivity. These findings suggest that, in this model, glutamate-receptor and sodium-channel coactivation are together needed to produce changes in tau immunoreactivity.

Citations

Apr 1, 1996·Molecular and Chemical Neuropathology·P CouratierJ Hugon
Aug 18, 2012·Molecular Neurobiology·Giovanna De ChiaraAnna Teresa Palamara
Jan 1, 1996·Fundamental & Clinical Pharmacology·P CouratierJ Hugon
Apr 30, 2009·Brain Research·Christopher S CasleyAnn E Kingston
Mar 13, 2003·Clinical Genetics·D Majoor-KrakauerA Hofman
Mar 9, 2004·American Journal of Alzheimer's Disease and Other Dementias·José L MolinuevoAmparo Villar
Apr 23, 2005·American Journal of Alzheimer's Disease and Other Dementias·José L MolinuevoLorena Rami
Dec 28, 2010·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Marcelo Vasconcelos Meireles

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