Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
A PerrottaFrancesco Pierelli

Abstract

Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR). In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2 mA, 15 min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects. Anodal tsDCS induced a long-lasting (up to 60 min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective. Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation. The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.

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Citations

May 31, 2017·Brain Connectivity·Lauren SchweizerTobias Schmidt-Wilcke
Nov 18, 2017·Scientific Reports·Amandine E ReyStéphanie Mazza
Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni
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Dec 12, 2020·Journal of Strength and Conditioning Research·Anthony B CicconeJoseph P Weir
Jul 1, 2021·Journal of Neurophysiology·Mauricio Carlos HenrichOle Kæseler Andersen

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