Modulation of the accumulation of inositol phosphates and the mobilization of calcium in aortic myocytes

European Journal of Pharmacology
P BertaJ C Cavadore

Abstract

In vascular smooth muscle cells the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA), a potent activator of C-kinase, inhibited the accumulation of inositol phosphates and the mobilization of calcium produced by several agonists. In the same way, TPA inhibited the fluoride-induced activation of phosphoinositide metabolism. These results suggest a C-kinase action at a post-receptor level. Moreover, the fluoride-induced accumulation of inositol phosphates shows the presence of one or more guanine nucleotide-binding proteins (G-proteins) in the regulation of receptor-phospholipase C coupling. This was confirmed by the use of N-ethylmaleimide and pertussis toxin. These results support the view that, in addition to the induction of sustained contractions, C-kinase can activate negative feedback mechanisms in aortic myocytes.

References

Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·P BertaJ C Cavadore
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A V SomlyoA Scarpa
Mar 11, 1986·European Journal of Pharmacology·H MenkesS H Snyder
Aug 14, 1986·Biochemical and Biophysical Research Communications·M M Gleason, S F Flaim

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