PMID: 45786Dec 1, 1978

Modulation of the acquisition and expression of immunity by Tilorone: I. Delayed-type hypersensitivity responses

Immunopharmacology
J R Kettman

Abstract

The chronic administration of Tilorone [(2,7-bis(diethylamino)ethoxy]fluoren-9-one) with antigen seems to prevent the generation of DTH effector cells. The administration of Tilorone proximal to DTH challenge blocks the expression of DTH. By local transfer of DTH effector cells, this latter effect can be shown to be due to the lack of nonspecific inflammatory cells. By the use of both systemic and local transfer systems, it is also shown that specific DTH effector cells from animals treated with Tilorone are unable to circulate in the normal manner. Overall, these experiments suggest that Tilorone does not block the generation of DTH effector cells, but it does greatly alter the expression of DTH. The relation between these effects and the known interferon induction capacity on Tilorone remains unclear.

Citations

Sep 18, 1970·Science·G D Mayer, R F Krueger
Feb 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·H MegelJ G Michael
Feb 1, 1971·The Journal of Infectious Diseases·E De Clercq, T C Merigan

Related Concepts

Spleen
Intravenous Injections
Human leukocyte interferon
Mice, Inbred DBA
Interferon
Leukocytes
Antigens
Interferons
Tilorone
Delayed Hypersensitivity

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