Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis

Molecular Carcinogenesis
F LarcherC J Conti

Abstract

Tumor angiogenesis is governed by a complex balance of positive and negative angiogenic factors. Development of chemically-induced mouse skin tumors appears to be highly dependent on an early burst of neovascularization. We have previously shown that Ha-ras-driven vascular endothelial growth factor (VEGF) expression plays a pivotal role in this process. However, the status of other critical positive and negative angiogenic factors throughout skin tumorigenesis has not been studied to the same extent. In the present study, we show that another VEGF family member, placenta growth factor (PlGF), was highly upregulated at all tumor stages in a ras-dependent manner. The study of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), ligands of receptor tyrosine kinase 2 (Tie-2), showed that while stroma-derived Ang-2 was increased, epidermal Ang-1 expression was completely abolished at early papilloma formation. Studies using epidermal tumor cell lines suggest that the disappearance of Ang-1 also depends on ras activation, extending the plethora of events controlled by this oncogene in mouse skin carcinogenesis. Our results indicated that tumor development occurred in a strong angiogenesis-prone scenario in which PlGF and Ang-2 acted co...Continue Reading

References

Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A B BianchiC J Conti
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Aug 1, 1972·The Journal of Experimental Medicine·M A GimbroneJ Folkman
Jun 1, 1995·The American Journal of Physiology·J M GleadleP J Ratcliffe
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Ferrara
Jan 19, 1999·Journal of Neuro-oncology·M NomuraH Yamamoto
Jan 20, 2000·Journal of the National Cancer Institute·J Folkman
Jan 20, 2000·Journal of the National Cancer Institute·C Y LiM W Dewhirst
Apr 15, 2000·The Journal of Biological Chemistry·I KimG Y Koh
Aug 22, 2000·The Journal of Investigative Dermatology·C M FaillaG Zambruno
Dec 20, 2000·The Journal of Investigative Dermatology·P M LacalS D'Atri
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·M Detmar
Jan 16, 2002·Oncogene·Carmen SegrellesJesús M Paramio

❮ Previous
Next ❯

Citations

Nov 29, 2013·Photodiagnosis and Photodynamic Therapy·Amira M Gamal-EldeenAbdel-Rahman B Abdel-Ghaffar
Mar 17, 2004·Seminars in Cancer Biology·Janusz Rak, Joanne L Yu
Mar 17, 2004·Seminars in Cancer Biology·Michael A Bachelor, G Tim Bowden
Nov 26, 2008·Nature Reviews. Cancer·Christian FischerPeter Carmeliet
Mar 20, 2013·BMC Cancer·Agnès FiguerasGabriel Capellà
Jan 10, 2012·Experimental & Molecular Medicine·Sandro De Falco
Jan 21, 2014·Cancer Chemotherapy and Pharmacology·Pasquale CironeCedo M Bagi
Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bigang LiuYinling Hu
May 14, 2011·Molecular Aspects of Medicine·Sònia TuguesLena Claesson-Welsh
Oct 14, 2014·The Journal of Investigative Dermatology·Nicole L WardJames T Elder
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Mahmoud T Abo-ElfadlMahmoud F M Zawrah
Mar 3, 2004·Free Radical Biology & Medicine·Vuokko L Kinnula, James D Crapo
Nov 27, 2009·Tissue Engineering. Part a·Marie-Hélène RochonLucie Germain
Dec 16, 2003·Cell Research·Linda J Metheny-Barlow, Lu Yuan Li
Jun 10, 2016·International Journal of Oncology·Samanta TauroneMarco Artico
Jul 1, 2017·Angiogenesis·Claire Viallard, Bruno Larrivée
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Dody Houston Billhaq, Seunghyung Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.