PMID: 2118485Sep 15, 1990Paper

Modulation of the antigenic phenotype of early-passage human melanoma cells derived from multiple autologous metastases by recombinant human leukocyte, fibroblast and immune interferon

International Journal of Cancer. Journal International Du Cancer
P GiacominiP G Natali

Abstract

We have investigated the relationship between in vitro cultivation of autologous melanoma metastases derived from different patients and their levels of expression of class-I and -II major histocompatibility complex (MHC) antigens and melanoma-associated antigens (MAAs). Cell cultures were established from 23 individual metastatic melanoma lesions from 10 patients and were tested early after isolation (between 3rd and 10th passages) for both constitutive expression and modulation by recombinant human leukocyte (IFN-alpha), fibroblast (IFN-beta) or immune (IFN-gamma) interferon of MHC antigens and MAA. All of the melanoma cell lines displayed altered antigen expression following IFN treatment. While in vitro cultures derived from different individuals varied in both constitutive and IFN-modified antigenic expression, cultures of autologous metastases derived from the same patient were very similar. In addition, differences in antigenic profile were apparent when early-passage in vitro cultures were compared with the same melanoma lesion, not established in culture, from which they were derived. The unique de novo and IFN-modified antigenic phenotype of cultures derived from different patients indicates that the antigenic phenoty...Continue Reading

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Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Jan 1, 1985·Pharmacology & Therapeutics·P B Fisher, S Grant
Jun 15, 1987·International Journal of Cancer. Journal International Du Cancer·P GiacominiP G Natali
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Citations

Jul 13, 2005·Cancer Immunology, Immunotherapy : CII·K L Knutson, M L Disis
Oct 1, 1995·Human Immunology·I de Waard-SiebingaM J Jager
Apr 1, 1995·American Journal of Obstetrics and Gynecology·S K Tyring
Jun 11, 2005·Experimental Dermatology·Mirjana UrosevicReinhard Dummer
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ian S DunnJames T Kurnick

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