PMID: 8590313Feb 1, 1995Paper

Modulation of the antilisterial activity of human blood-derived macrophages by activating and deactivating cytokines

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
F BläuerA Schaffner

Abstract

A concept of macrophage deactivation by hormones and cytokines that opposes activation was recently proposed. Deactivation of the antilisterial activity of macrophages by IL-4, IL-10, and TGF-beta, as well as by dexamethasone, was studied here. IL-4, IL-10, and dexamethasone, but not TGF-beta, caused a complete loss of the competence of human blood-derived macrophages infected with Listeria monocytogenes to control or eliminate ingested bacteria. IL-10 and, to a lesser degree, dexamethasone lessened in parallel the capacity of macrophages to secrete H2O2. The antilisterial activity of cells simultaneously exposed to deactivating agents could be significantly augmented by IFN-gamma. Likewise, TNF-alpha and to a limited degree GM-CSF increased the antilisterial activity of cells treated with IL-10 and dexamethasone but not that of cells treated with IL-4. Suppression of TNF-alpha secretion in response to Listeria by TGF-beta, IL-10, dexamethasone, or pentoxifylline did not closely parallel antilisterial activity. Studies by transmission electron microscopy and actin staining suggested that deactivation by IL-10, IL-4, and dexamethasone of human blood-derived macrophages resulted in intraphagosomal multiplication of Listeria follo...Continue Reading

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Citations

Apr 7, 2005·Histochemistry and Cell Biology·Elisabeth EpplerPeter Groscurth
Dec 5, 1998·Veterinary Immunology and Immunopathology·G A DeanN C Pedersen
Feb 24, 2001·Clinical and Experimental Immunology·A L LaursenS Ellermann-Eriksen
Jun 10, 1997·Human Gene Therapy·P B McCrayB L Davidson
Aug 1, 1997·Immunological Reviews·S D Fleming, P A Campbell
Jul 8, 2008·International Immunopharmacology·Antonietta RizzoCaterina Romano Carratelli
Jun 23, 2009·Annals of the New York Academy of Sciences·Eric GhigoJean-Louis Mege
Dec 2, 2008·Microbiology and Immunology·Antonietta RizzoCaterina Romano Carratelli
Dec 16, 2003·Journal of Leukocyte Biology·Ahmed El-GedailyAndreas Schaffner
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Junichi SasakiNaoki Aikawa

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