Modulation of the apelin/APJ system in heart failure and atherosclerosis in man.

British Journal of Pharmacology
Sarah L PitkinAnthony P Davenport

Abstract

The aim of this study was to determine whether the apelin/APJ system is altered in human cardiovascular disease by investigating whether the expression of apelin or its receptor is altered at the protein level. Radioligand binding studies were used to determine apelin receptor density in human cardiac tissues. Apelin peptide levels in cardiovascular tissues were determined by radioimmunoassay. In vitro pharmacology was used to assess vasoactive properties of apelin in human coronary artery. Localization of apelin and its receptor in coronary artery was determined using immunohistochemistry. Apelin receptor density was significantly decreased in left ventricle from patients with dilated cardiomyopathy or ischaemic heart disease compared with controls, but apelin peptide levels remained unchanged. Apelin was up-regulated in human atherosclerotic coronary artery and this additional peptide localized to the plaque, colocalizing with markers for macrophages and smooth muscle cells. Apelin potently constricted human coronary artery. We have detected changes in the apelin/APJ system in human diseased cardiac and vascular tissue. The decrease in receptor density in heart failure may limit the positive inotropic actions of apelin, contr...Continue Reading

References

Dec 8, 1994·The New England Journal of Medicine·G W Dec, V Fuster
Oct 30, 1998·Biochemical and Biophysical Research Communications·K TatemotoM Fujino
Aug 14, 2003·Biochemical and Biophysical Research Communications·Gábor FöldesMiklós Tóth
Sep 10, 2003·Circulation·Mary M ChenThomas Quertermous
Sep 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard MasriYves Audigier
Nov 9, 2004·Biochemical and Biophysical Research Communications·Atsushi KasaiAkemichi Baba
Dec 17, 2004·Cellular Signalling·B MasriY Audigier
Dec 29, 2004·Cardiovascular Research·Euan A AshleyThomas Quertermous
May 24, 2005·Pharmacology & Therapeutics·Matthias J Kleinz, Anthony P Davenport
Feb 9, 2006·European Journal of Heart Failure·Kwok Shiong ChongTheresa A McDonagh
Mar 15, 2006·Trends in Pharmacological Sciences·Dennis K LeeBrian F O'Dowd
Nov 23, 2006·Cellular & Molecular Biology Letters·Pavan AtluriY Joseph Woo
Mar 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veli-Pekka RonkainenPasi Tavi
Jul 14, 2007·Regulatory Peptides·Adely SalcedoGodofredo Diéguez
Aug 19, 2007·Basic Research in Cardiology·James C SimpkinChristopher C T Smith
Sep 22, 2007·The American Journal of Pathology·Tatsuo HashimotoSatoshi Umemura
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ahmad Y SheikhThomas Quertermous
Feb 15, 2008·Biochemical Pharmacology·Alan G Japp, David E Newby
May 7, 2008·Journal of Physiology and Biochemistry·C CarpénéI Castan-Laurell
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Feng LiLinxi Chen
Sep 5, 2008·The Journal of Clinical Investigation·Hyung J ChunThomas Quertermous
Sep 6, 2008·Journal of the American College of Cardiology·Alan G JappDavid E Newby
Mar 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Nicholas J LeeperThomas Quertermous
May 26, 2009·Peptides·Xiang Jun ZengChao Shu Tang

❮ Previous
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Citations

Aug 15, 2013·The Journal of Endocrinology·Anne-Marie O'CarrollGeorge R Pope
Mar 29, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christos G KostopoulosHelen H Papadaki
Jun 2, 2012·Cardiology Research and Practice·Seyyed M R Kazemi-BajestaniGavin Y Oudit
Sep 24, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Hua YuChao-Ke Tang
Aug 30, 2013·Canadian Journal of Physiology and Pharmacology·Xue HanWen-Hu Liu
Jun 1, 2012·Expert Opinion on Drug Discovery·Christopher J Charles
Dec 5, 2015·Blood·Frédéric AdamGeraldine Siegfried
Oct 10, 2014·Thrombosis and Haemostasis·P CirilloB Trimarco
Oct 5, 2012·European Journal of Clinical Investigation·Nikolaos P E KadoglouChristos D Liapis
Sep 20, 2015·Biochemical and Biophysical Research Communications·Feng YaoChao-Ke Tang
Feb 6, 2015·Heart Failure Reviews·Anna FolinoRaffaella Rastaldo
Mar 22, 2015·Journal of Cardiac Failure·Jonathan R DalzellJohn J V McMurray
Dec 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Agnieszka M TycinskaBozena Sobkowicz
Jun 5, 2014·Chinese Journal of Integrative Medicine·Hong-Liang KongRu-ming Guan
Apr 17, 2013·Acta Biochimica Et Biophysica Sinica·Deguan LvLinxi Chen
Jun 6, 2017·Cardiovascular Research·Ioannis Akoumianakis, Charalambos Antoniades
Dec 6, 2011·Pulmonary Circulation·Charlotte U AndersenU Simonsen
Dec 8, 2017·Journal of Cellular Physiology·Xuling LuoLinxi Chen
Jan 6, 2018·Frontiers in Physiology·Ying ZhouLiang Yin
Mar 15, 2018·Journal of Experimental Neuroscience·Elizabeth Harford-Wright, Julie Gavard
May 12, 2011·ChemMedChem·N J Maximilian MacalusoRobert C Glen
Mar 16, 2017·Hypertension·Francesca SchinzariManfredi Tesauro
Apr 23, 2019·Medicinal Research Reviews·Kannan R R RengasamyShunmugiah Karutha Pandian
May 19, 2018·The Journal of Pharmacology and Experimental Therapeutics·Amreen MughalStephen T O'Rourke
Jun 22, 2017·Clinical and Experimental Hypertension : CHE·Agnieszka JędzuraMaria Szczepańska
Jun 5, 2020·Nature Reviews. Drug Discovery·Anthony P DavenportJanet J Maguire
Jun 27, 2019·Annals of the New York Academy of Sciences·Eric MarsaultMannix Auger-Messier
Nov 9, 2018·Disease Markers·Larisa-Diana Mocan HognogiAnca-Daniela Farcaş
Sep 22, 2020·ELife·Christian Sm HelkerDidier Yr Stainier
Mar 26, 2020·JCI Insight·Brandon AsonAarif Y Khakoo
May 29, 2018·Pharmacology & Therapeutics·Amreen Mughal, Stephen T O'Rourke
Jul 13, 2019·Life Sciences·Mohammad Kazemi ArababadiGholamreza Asadikaram

❮ Previous
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