PMID: 18719382Aug 23, 2008Paper

Modulation of the "blood-tumor" barrier improves immunotherapy

Cell Cycle
Mitali ManzurRuth Ganss

Abstract

Blood vessels inside tumors are crucial for cancer survival and progression but equally contribute to the tumor's intrinsic resistance to therapy. Abnormal blood flow in the local tumor environment acts as a physiological barrier to the delivery of chemotherapeutic agents. Furthermore, tumor vasculature can also act as a barrier for immune cell migration into the tumor parenchyma. Much has been made of anti-angiogenic therapies that specifically inhibit vessel growth. However, recent findings demonstrate that the chaotic architecture of tumor blood vessels can be reversed which in turn normalizes blood flow and physical parameters in the tumor environment. Importantly, vessel normalization also improves lymphocyte migration into tumor tissue and immune destruction. Identification of regulator of G protein signaling 5 (RGS5) as a key modulator of the vascular barrier in tumor progression and regression has brought new insights into the molecular basis of vessel normalization and opens new therapeutic opportunities.

Citations

Dec 30, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xi ZhaoWalter J Storkus
May 14, 2010·Journal of the National Cancer Institute·Olaf PenackMarcel R M van den Brink
Nov 26, 2010·World Journal of Gastroenterology : WJG·Jing-Hua WangLong-Bang Chen
May 27, 2009·Trends in Cardiovascular Medicine·Mitali Manzur, Ruth Ganss
Nov 13, 2010·European Journal of Immunology·Xingrui LiGünter J Hämmerling
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Feb 18, 2015·Frontiers in Oncology·Leonel AmpieChristopher Dardis
May 7, 2016·Journal of Translational Medicine·V LeuciD Sangiolo
Jan 1, 2012·Cancers·Anna Johansson, Ruth Ganss
Sep 3, 2020·Journal of the American Heart Association·Nikola SladojevicJames K Liao
Jan 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xi ZhaoWalter J Storkus

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