Modulation of the cardiac pacemaker of Drosophila: cellular mechanisms

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
E JohnsonHarold Dowse

Abstract

The myogenic cardiac pacemaker of Drosophila melanogaster responds to a range of neurotransmitters and hormones by adjusting heart rate. These cardioactive substances ultimately affect the activity of ion channels comprising the pacemaker. We report here work utilizing genetic variants and pharmacological tools to explore a subset of possible mechanisms for this cellular signaling, specifically: receptors, cAMP, cGMP, G proteins, and calcium. We found that alpha(1) adrenergic and 5-hydroxytryptamine(2) (5-HT(2)) receptors are critical components of mediating modulation of heart rate. There was no evidence that the cAMP system is part of the modulatory mechanism. cGMP is likely to be integral to one active pathway, as non-hydrolyzable forms of this cyclic nucleotide increase heart rate, and flies bearing the mutation sitter, a recessive allele of the foraging gene, which encodes a cGMP-dependent kinase, have tachycardia. Heart rhythm is affected by pertussis toxin and by agonists and antagonists of both alpha(1) adrenergic and 5-HT(2) receptors; this suggests involvement of two different types of G proteins. The l(4)16/ciD line, containing a mutation in CaM kinase II, eliminates pacemaker responsiveness to serotonin but is witho...Continue Reading

Citations

Dec 2, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Subhabrata SanyalMani Ramaswami
Dec 20, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Sameera Dasari, Robin L Cooper
Sep 17, 2011·Circulation Research·Matthew J Wolf, Howard A Rockman
Nov 18, 2009·Journal of Visualized Experiments : JoVE·Ann S CooperRobin L Cooper
Dec 29, 2013·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Zana R MajeedRobin L Cooper
May 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Erik C JohnsonPaul H Taghert
Dec 5, 2013·Physiological Reports·Josh S TitlowRobin L Cooper
Jul 29, 2009·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Tricia JenningsHarold Dowse
Mar 15, 2006·Brain Research·Andrew F M Johnstone, Robin L Cooper
Jun 24, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Julián F HillyerHoma E Mirzai
Apr 15, 2015·Journal of Insect Physiology·Jonas Lembcke AndersenJohannes Overgaard
Aug 8, 2006·Current Biology : CB·Nathalie LalevéeMichel Sémériva
Sep 20, 2005·Developmental Biology·Verónica G Rodriguez Moncalvo, Ana Regina Campos
May 23, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yue Chen ZhuRobin L Cooper
Jul 23, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Tricia VanKirkHarold B Dowse
Jan 28, 2017·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Vernon Beasley, Harold Dowse
May 8, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Robert E Poelmann, Adriana C Gittenberger-de Groot
Oct 5, 2013·Journal of Applied Physiology·Zana R MajeedRobin L Cooper
Sep 16, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Danielle F FelicianoJosé W M Bassani
Aug 31, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kate E BroderickGerry R Boss
Sep 10, 2020·Scientific Reports·Yusaku IkedaYasushi Sako
Mar 9, 2021·Frontiers in Cardiovascular Medicine·Meihua SheQun Zeng
Apr 24, 2018·Journal of Molecular and Cellular Cardiology·Worawan B LimpitikulAnthony Cammarato
Jul 31, 2004·BioTechniques·Robert J Wessells, Rolf Bodmer

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