PMID: 9447864Feb 3, 1998Paper

Modulation of the cardiac sodium current by inhalational anesthetics in the absence and presence of beta-stimulation

Anesthesiology
H U WeigtZ J Bosnjak

Abstract

Cardiac dysrhythmias during inhalational anesthesia in association with catecholamines are well known, and halothane is more "sensitizing" than isoflurane. However, the underlying mechanisms of action of volatile anesthetics with or without catecholamines on cardiac Na channels are poorly understood. In this study, the authors investigated the effects of halothane and isoflurane in the absence and presence of beta-stimulation (isoproterenol) on the cardiac Na+ current (INa) in ventricular myocytes enzymatically isolated from adult guinea pig hearts. A standard whole-cell patch-clamp technique was used. The INa was elicited by depolarizing test pulses from a holding potential of -80 mV in reduced Na+ solution (10 mM). Isoproterenol alone depressed peak INa significantly by 14.6 +/- 1.7% (means +/- SEM). Halothane (1.2 mM) and isoflurane (1.0 mM) also depressed peak INa significantly by 42.1 +/- 3.4% and 21.3 +/- 1.9%, respectively. In the presence of halothane, the effect of isoproterenol (1 microM) was potentiated, further decreasing peak INa by 34.7 +/- 4.1%. The halothane effect was less, although significant, in the presence of a G-protein inhibitor (GDPbetaS) or a specific protein kinase A inhibitor [PKI-(6-22)-amide], redu...Continue Reading

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Citations

Oct 27, 2005·Anesthesiology·Markus W HollmannMarcel E Durieux
Sep 15, 2015·Journal of Neurochemistry·Andrea Crespo-CastrilloAntonio G García
Apr 23, 2004·Acta Anaesthesiologica Scandinavica·R HünekeA Lückhoff
Jul 3, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Mark W CrawfordRobert Gow
Oct 13, 2016·Experimental Physiology·Julliane Vasconcelos Joviano-SantosAnderson José Ferreira
Oct 24, 2019·Clinical and Experimental Pharmacology & Physiology·Julliane V Joviano-SantosAnderson J Ferreira

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