PMID: 8986785Dec 24, 1996Paper

Modulation of the chaperone-like activity of bovine alpha-crystallin

Proceedings of the National Academy of Sciences of the United States of America
J I Clark, Q L Huang

Abstract

The effects of pantethine, glutathione, and selected chemical reagents on the anti-aggregation activity of alpha-crystallin was evaluated. Protein aggregation was monitored by light scattering of solutions of denatured beta L-crystallin or alcohol dehydrogenase (ADH). The ratios of beta L-crystallin/alpha-crystallin and ADH/alpha-crystallin were adjusted so that partial inhibition of protein aggregation at 60 degrees C or 37 degrees C, respectively, was observed and modulation of the chaperone action of alpha-crystallin could be evaluated easily with selected endogenous metabolites. Enhancement of the anti-aggregation activity in the beta L-crystallin assay was strongest with pantethine, which appeared to interact with alpha-crystallin. Enhancement of the anti-aggregation activity in the ADH assay was strongest with glutathione which appeared to interact with ADH. The results indicated that the products of common metabolic pathways can modulate the chaperone-like effects of alpha-crystallin on protein aggregation.

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Citations

May 16, 2009·Applied Biochemistry and Biotechnology·Abolfazl BarzegarNader Sheibani
Mar 8, 2011·Cell Stress & Chaperones·Shuhua SongToshimichi Shinohara
Mar 1, 2014·Progress in Biophysics and Molecular Biology·Wilbert C Boelens
Oct 15, 2003·Biophysical Chemistry·Keyang Wang, Boris I Kurganov
Feb 19, 2000·Current Opinion in Structural Biology·J I Clark, P J Muchowski
Aug 8, 1998·Progress in Retinal and Eye Research·J Piatigorsky
Apr 27, 1999·Progress in Retinal and Eye Research·B K Derham, J J Harding
Nov 14, 2002·Biochimica Et Biophysica Acta·Olesya O PanasenkoNikolai B Gusev
Jul 21, 2011·Photochemistry and Photobiology·Marilyn EhrenshaftJoan E Roberts
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·P J Muchowski, J I Clark
Sep 16, 2008·The Journal of Nutritional Biochemistry·Pasupulati Anil KumarGeereddy Bhanuprakash Reddy
Jul 28, 2016·International Journal of Biological Macromolecules·Boris I Kurganov
Jan 31, 2006·Biochimica Et Biophysica Acta·J G MasilamoniR Jayakumar
Jun 5, 2018·Fundamental & Clinical Pharmacology·Amany Abdel-GhaffarRawda G Mohamed
May 23, 2003·Protein Science : a Publication of the Protein Society·Volety SrinivasCh Mohan Rao
Apr 25, 2009·IUBMB Life·Pasupulati Anil Kumar, Geereddy Bhanuprakash Reddy
Jun 10, 2005·The FEBS Journal·Yu Sun, Thomas H MacRae
Mar 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John I Clark
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Mar 14, 2008·International Journal of Biological Macromolecules·Abolfazl BarzegarAli Akbar Moosavi-Movahedi
May 26, 2009·Biochimica Et Biophysica Acta·K Krishna Sharma, Puttur Santhoshkumar

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