Modulation of the expression of early genes by polyunsaturated fatty acids

Prostaglandins, Leukotrienes, and Essential Fatty Acids
A SellmayerP C Weber

Abstract

Expression of early genes is a characteristic immediate cellular response to mitogenic or inflammatory stimulation. Various second messenger systems have been found to transduce the signal from the plasma membrane to the nucleus. Recent observations indicate that in addition to well characterized second messenger systems, polyunsaturated fatty acids, especially the n-6 fatty acid arachidonic acid and its endogenously produced metabolites affect the expression of early genes in different cell types. At least in fibroblasts, the stimulatory effect of arachidonic acid can be antagonized by n-3 polyunsaturated fatty acids. Further identification of the mechanisms through which polyunsaturated fatty acids modulate early gene expression and regulate subsequent cellular responses, like cell growth, may help to define novel concepts in the management of cardiovascular diseases.

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Citations

Nov 26, 1999·Journal of Cellular Biochemistry·M T Rizzo, W m Yu
Dec 10, 2009·Neurochemical Research·Ho-Joo LeeAbesh Kumar Bhattacharjee
Jan 12, 2000·Molecular and Cellular Endocrinology·X Wang, D M Stocco
May 3, 2013·Lipids in Health and Disease·Chenyu Huang, Rei Ogawa
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Jan 16, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E A Nunez
Jun 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Maria Teresa Rizzo
Jan 6, 2006·The American Journal of Gastroenterology·B TjellströmE Norin
Sep 22, 2006·Biotechnology Letters·Yoshitake OrikasaHidetoshi Okuyama
Jan 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ji Young KimCynthia M Smas
Oct 31, 2001·Public Health Nutrition·S Renaud, D Lanzmann-Petithory
Jul 27, 1999·Lipids·A SellmayerP C Weber

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