PMID: 15225127Jul 1, 2004Paper

Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids

The Journal of Endocrinology
Malika Robichaud, Guy Debonnel

Abstract

Important gender differences in mood disorders result in a greater susceptibility for women. Accumulating evidence suggests a reciprocal modulation between the 5-hydroxytryptamine (5-HT) system and neuroactive steroids. Previous data from our laboratory have shown that during pregnancy, the firing activity of 5-HT neurons increases in parallel with progesterone levels. This study was undertaken to evaluate the putative modulation of the 5-HT neuronal firing activity by different neurosteroids. Female rats received i.c.v. for 7 days a dose of 50 micro g/kg per day of one of the following steroids: progesterone, pregnenolone, 5beta-pregnane-3,20-dione (5beta-DHP), 5beta-pregnan-3alpha-ol,20-one, 5beta-pregnan-3beta-ol,20-one, 5alpha-pregnane-3,20-dione, 5alpha-pregnan-3alpha-ol,20-one (allopregnanolone, 3alpha,5alpha-THP), 5alpha-pregnane-3beta-ol,20-one and dehydroepiandrosterone (DHEA). 5beta-DHP and DHEA were also administered for 14 and 21 days (50 micro g/kg per day, i.c.v.) as well as concomitantly with the selective sigma 1 (sigma1) receptor antagonist NE-100. In vivo, extracellular unitary recording of 5-HT neurons performed in the dorsal raphe nucleus of these rats revealed that DHEA, 5beta-DHP and 3alpha,5alpha-THP sign...Continue Reading

Citations

Apr 12, 2007·Bulletin of Experimental Biology and Medicine·A E Lychkova, V B Potapova
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Lee E SchechterSharon Rosenzweig-Lipson
May 23, 2014·The Journal of Steroid Biochemistry and Molecular Biology·M HillL Stárka
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Jul 22, 2009·Pharmacology & Therapeutics·Tangui Maurice, Tsung-Ping Su
Jan 2, 2009·Psychoneuroendocrinology·Julie EspallerguesTangui Maurice
May 9, 2012·Depression and Anxiety·Emma M SteinbergPeter J Schmidt
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Mar 7, 2021·International Journal of Molecular Sciences·Jan Jakubík, Esam E El-Fakahany
May 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shiyi ChenYiping Ye

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