PMID: 9450940Mar 7, 1998Paper

Modulation of the frequency of spontaneous sarcoplasmic reticulum Ca2+ release events (Ca2+ sparks) by myoplasmic [Mg2+] in frog skeletal muscle

The Journal of General Physiology
Alain LacampagneM F Schneider

Abstract

The modulation by internal free [Mg2+] of spontaneous calcium release events (Ca2+ "sparks") from the sarcoplasmic reticulum (SR) was studied in depolarized notched frog skeletal muscle fibers using a laser scanning confocal microscope in line-scan mode (x vs. t). Over the range of [Mg2+] from 0.13 to 1.86 mM, decreasing the [Mg2+] induced an increase in the frequency of calcium release events in proportion to [Mg2+]-1.6. The change of event frequency was not due to changes in [Mg-ATP] or [ATP]. Analysis of individual SR calcium release event properties showed that the variation in event frequency induced by the change of [Mg2+] was not accompanied by any changes in the spatiotemporal spread (i.e., spatial half width or temporal half duration) of Ca2+ sparks. The increase in event frequency also had no effect on the distribution of event amplitudes. Finally, the rise time of calcium sparks was independent of the [Mg2+], indicating that the open time of the SR channel or channels underlying spontaneous calcium release events was not altered by [Mg2+] over the range tested. These results suggest that in resting skeletal fibers, [Mg2+] modulates the SR calcium release channel opening frequency by modifying the average closed time ...Continue Reading

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Citations

Aug 7, 2007·Pflügers Archiv : European journal of physiology·Carlo Caputo, Pura Bolaños
Mar 9, 2005·Biochemical and Biophysical Research Communications·Pascal SirventAlain Lacampagne
Jun 20, 2001·Acta Physiologica Scandinavica·W Melzer, B Dietze
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·A GonzálezE Ríos
Feb 2, 1999·The Journal of General Physiology·A LacampagneM F Schneider
Mar 3, 1999·The Journal of General Physiology·N ShirokovaH Cheng
Jul 10, 1999·The Journal of General Physiology·E RíosN Shirokova
Feb 2, 2000·The Journal of General Physiology·A GonzálezE Ríos
Nov 28, 2001·The Journal of General Physiology·S HollingworthS M Baylor
Jan 5, 2002·The Journal of General Physiology·Alexander ShtifmanMartin F Schneider
Mar 19, 2003·The Journal of General Physiology·W K ChandlerS M Baylor
Nov 26, 2008·The Journal of General Physiology·Konstantin Gusev, Ernst Niggli
Apr 16, 2005·The Journal of Pharmacology and Experimental Therapeutics·Yingfan ZhangMartin F Schneider
Mar 16, 2001·Journal of Basic and Clinical Physiology and Pharmacology·D KrausR Rahamimoff
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·A LacampagneM F Schneider
May 16, 2000·The Journal of Physiology·C W WardP D Allen
Feb 9, 2012·The Journal of Physiology·Lourdes FigueroaEduardo Ríos
Oct 9, 1998·The Journal of Physiology·N ShirokovaE Ríos
Jan 25, 2012·Toxicology and Applied Pharmacology·P SirventJ Mercier
Mar 9, 2018·The Journal of General Physiology·Eduardo Ríos
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Nov 1, 2003·American Journal of Physiology. Cell Physiology·Feliciano ProtasiPaul D Allen
Aug 14, 1999·The Journal of General Physiology·M FillA Escobar
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C W WardA Lacampagne
Sep 5, 2003·American Journal of Physiology. Cell Physiology·Alexander ShtifmanFeliciano Protasi
Aug 16, 2000·American Journal of Physiology. Cell Physiology·B R FruenC F Louis
Jan 11, 2005·The Journal of Biological Chemistry·George G RodneyMartin F Schneider
Aug 30, 2005·Progress in Biophysics and Molecular Biology·Michael G Klein, Martin F Schneider
Nov 23, 2019·Free Radical Biology & Medicine·Haikel DridiStephan Matecki
Oct 14, 2008·Methods : a Companion to Methods in Enzymology·Natalia Shirokova, Ernst Niggli
Jul 30, 2003·Biophysical Journal·George G Rodney, Martin F Schneider
Nov 5, 1999·Biophysical Journal·Y H JiangM F Schneider

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