Modulation of the host flora

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
R van Furth, H F Guiot

Abstract

Modulation of the bacterial flora of patients with a high risk of acquiring an infection can be achieved in several ways. The approach used in the Leiden University Hospital is based on selective elimination of the aerobic bacteria in the oropharyngeal cavity and intestinal tract, leaving the anaerobic flora intact. This kind of selective modulation of the host flora has an advantage in that it does not affect the colonization resistance provided by bacterial antagonism, which prevents colonization by resistant but potentially pathogenic bacteria or fungi. The elimination of aerobic bacteria combined with nursing in protective isolation and consumption of food with few bacteria has led to a significant reduction of the incidence of major and fatal infections in patients during episodes of severe granulocytopenia. From these results it may be concluded that the objective of selective antibiotic modulation, namely, the prevention of infections, can be achieved with this approach.

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Citations

Dec 1, 1992·Epidemiology and Infection·H F Guiot, R van Furth
Sep 1, 1991·The Journal of Hospital Infection·H K van Saene, A Percival
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Miguel Navasa, Juan Rodés
Apr 1, 1992·The British Journal of Surgery·G W TetterooH A Bruining
Jun 15, 2010·Journal of Neurosurgery·Matthew R ReynoldsRalph G Dacey
Jan 22, 2015·The New Phytologist·Colin E Hughes, Guy W Atchison
Aug 1, 1991·Applied and Environmental Microbiology·S E GeorgeL D Claxton
Jun 1, 1990·Applied and Environmental Microbiology·S E GeorgeL D Claxton

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